High number of PD-1 positive intratumoural lymphocytes predicts survival benefit of cytokine-induced killer cells for hepatocellular carcinoma patients.
High number of PD-1 positive intratumoural lymphocytes predicts survival benefit of cytokine-induced killer cells for hepatocellular carcinoma patients.
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DOI：
10.1111/liv.13697
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Wu P
中科院分区：
文献类型：
--
作者：
Chang B;Shen L;Wang K;Jin J;Huang T;Chen Q;Li W;Wu P
辅助细胞因子诱导杀伤（CIK）细胞治疗已显示出降低复发率和延长肝细胞癌（HCC）患者生存期的潜力。我们的目的是确定HCC患者根治性切除后CIK细胞辅助治疗的最佳预测生物标志物。本研究回顾性纳入145对HCC患者，采用一对一倾向评分匹配。一组术后输血CIK细胞（手术- CIK组）；另一组只接受手术治疗（手术组）。采用免疫组化（IHC）技术检测手术- CIK组肿瘤组织中PD‐1、PD‐L1、CD4、CD8和Foxp3的表达；仅在手术组进行PD‐1和PD‐L1的免疫组化。与仅手术组相比，手术- CIK组的无病生存率（DFS）和总生存率（OS）明显更高。在所有肿瘤内生物标志物中，在手术- CIK组中，多变量分析显示，大量PD - 1+肿瘤浸润淋巴细胞（til）是独立预测有利的OS和DFS的唯一因素。相比之下，在仅手术组中，PD‐1/PD‐L1表达与患者生存之间没有显著相关性。进一步的相关性分析显示，在手术- CIK组中，PD - 1+ TILs的高数量与CD4+和CD8+ TILs的高数量相关。大量PD‐1+ TILs可以作为HCC患者根治性切除后采用CIK细胞治疗的有效生物标志物。
Adjuvant cytokine‐induced killer (CIK) cells treatment has shown potential in reducing the recurrence rate and prolonging the survival of patients with hepatocellular carcinoma (HCC). We aimed to identify the best predictive biomarker for adjuvant CIK cells treatment in patients with HCC after curative resection. This study retrospectively included 145 pairs of HCC patients by one‐to‐one propensity score matching. One group received CIK cells transfusion after surgery (surgery‐CIK group); the other one group underwent surgery only (surgery‐only group). Immunohistochemistry (IHC) was used to measure PD‐1, PD‐L1, CD4, CD8 and Foxp3 expression in tumour tissues of surgery‐CIK group; IHC of PD‐1 and PD‐L1 was conducted in the surgery‐only group. The surgery‐CIK group had a significantly higher disease‐free survival (DFS) and overall survival (OS) rates compared to the surgery‐only group. Of all the intratumoural biomarkers, in the surgery‐CIK group, multivariate analysis showed that a high number of PD‐1+ tumour infiltrative lymphocytes (TILs) was the only factor that independently predicted favourable OS and DFS. By contrast, in the surgery‐only group, no significant correlations between PD‐1/PD‐L1 expression and survival of patients were identified. Further correlation analysis showed a high number of PD‐1+ TILs associated with a high number of both CD4+ and CD8+ TILs in surgery‐CIK group. A high number of PD‐1+ TILs can serve as a potent biomarker for adopting CIK cells therapy in HCC patients after curative resection.
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影响因子：
3.7
作者：
Schmidt LH;Kümmel A;Görlich D;Mohr M;Bröckling S;Mikesch JH;Grünewald I;Marra A;Schultheis AM;Wardelmann E;Müller-Tidow C;Spieker T;Schliemann C;Berdel WE;Wiewrodt R;Hartmann W
通讯作者：
Hartmann W
影响因子：
8.6
作者：
Shi, Ming;Fu, Junliang;Wang, Fu-Sheng
通讯作者：
Wang, Fu-Sheng
PD-1，PD-1配体的关联以及肿瘤免疫微环境的其他特征与抗PD-1治疗的响应。
DOI：
10.1158/1078-0432.ccr-13-3271
发表时间：
2014-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Taube JM;Klein A;Brahmer JR;Xu H;Pan X;Kim JH;Chen L;Pardoll DM;Topalian SL;Anders RA
通讯作者：
Anders RA
细胞因子诱导的杀伤（CIK）细胞：从基础研究到临床转化。
影响因子：
--
作者：
Guo Y;Han W
通讯作者：
Han W
影响因子：
17.1
作者：
Taube JM;Anders RA;Young GD;Xu H;Sharma R;McMiller TL;Chen S;Klein AP;Pardoll DM;Topalian SL;Chen L
通讯作者：
Chen L