The Role of Spirochetes in Periodontal Disease

The Role of Spirochetes in Periodontal Disease
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螺旋体在牙周病中的作用

DOI:
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发表时间:
1988
影响因子:
--
通讯作者:
Wj Loesche
Wj Loesche
中科院分区:
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文献类型:
--
作者:
Wj Loesche

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龈下菌斑中螺旋体的积累似乎与牙周病的临床严重程度有关。目前尚不清楚有多少种不同的螺旋体在斑块上定居,但仅根据大小,可分为小型、中型和大型螺旋体。四种小螺旋体是可培养的,其中,T. denticola 已被证明具有蛋白水解酶和角蛋白分解酶以及抑制淋巴细胞胚细胞发生和抑制成纤维细胞和多形核白细胞 (PMNL) 功能的因子或机制。所有这些属性都可能导致牙周组织损伤。然而,独立于这些潜在的毒力机制,如果简单地解释为指示组织损伤的结果,螺旋体的过度生长在临床上是有用的。在这种情况下,螺旋体将成为疾病的指标,并且可以通过斑块的显微镜检查或可能通过测量斑块中的苯甲酰基-DL-精氨酸-2-萘酰胺(BANA)水解活性来轻松监测。
The spirochetal accumulation in subgingival plaque appears to be a function of the clinical severity of periodontal disease. It is not known how many different spirochetal species colonize the plaque, but based upon size alone, there are small, intermediate-sized, and large spirochetes. Four species of small spirochetes are cultivable, and of these, T. denticola has been shown to possess proteolytic and keratinolytic enzymes as well as factors or mechanisms which suppress lymphocyte blastogenesis and inhibit fibroblast and polymorphonuclear leukocyte (PMNL) function. All of these attributes could contribute to periodontal tissue insult. Yet independent of these potential virulence mechanisms, the overgrowth of spirochetes can be clinically useful if simply interpreted as indicating the result of tissue damage. In this case, the spirochetes would be indicators of disease and could be easily monitored by microscopic examination of plaque, or possibly by the measurement of benzoyl-DL-arginine-2-naphthylamide (BANA) hydrolytic activity in the plaque.
DOI: --
发表时间: 1984
期刊: The International journal of periodontics & restorative dentistry
影响因子: --
作者:
Listgarten,MA
通讯作者: Listgarten,MA
口腔螺旋体抑制人类淋巴细胞反应:单核细胞依赖性现象。
DOI: --
发表时间: 1984
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Shenker,BJ;Listgarten,MA;Taichman,NS
通讯作者: Taichman,NS
人类中性粒细胞与斑块螺旋体相互作用的研究。
DOI: 10.1111/j.1600-0765.1986.tb01452.x
发表时间: 1986
影响因子: 3.5
作者:
Boehringer,H;Berthold,PH;Taichman,NS
通讯作者: Taichman,NS
牙周病中口腔螺旋体的病理学。
DOI: 10.1111/j.1600-0765.1982.tb02023.x
发表时间: 1982
影响因子: 3.5
作者:
Taichman,NS;Bohringer,HR;Lai,CH;Shenker,BJ;Tsai,CC;Berthold,PH;Listgarten,MA;Shapiro,IS
通讯作者: Shapiro,IS