Cutting Edge: CD4+ T Cell-Derived IL-2 Is Essential for Help-Dependent Primary CD8+ T Cell Responses1
Cutting Edge: CD4+ T Cell-Derived IL-2 Is Essential for Help-Dependent Primary CD8+ T Cell Responses1
复制标题
前沿技术：CD4 T 细胞衍生的 IL-2 对于帮助依赖性初级 CD8 T 细胞反应至关重要1
作者：
Elizabeth B. Wilson;A. Livingstone
CD4+ T 细胞的帮助对于 CD8+ T 细胞对非炎症性抗原的初级反应至关重要。 IL-2 是由初始 CD4+ T 细胞产生的主要细胞因子之一，我们在这项研究中表明它是帮助的重要组成部分。过继转移的初始 CD4+ TCR 转基因 OT-II 细胞支持内源性初级 CD8+ T 细胞应答，但 IL-2 缺陷的 OT-II 细胞无法提供帮助，尽管它们在体内对 Ag 做出反应并在体外上调 CD40 配体。野生型OT-II细胞有助于IL-2缺陷型小鼠的内源性CD8+T细胞反应，但对IL-2Rα缺陷型小鼠则无帮助。因此，CD4+ T 细胞衍生的 IL-2 对于 CD8+ T 细胞对非炎症性细胞相关 Ag 的反应至关重要。我们认为它也是帮助 CD8+ T 细胞对病原体作出反应的关键组成部分，因为保护性记忆也需要在启动过程中通过 IL-2 刺激 CD8+ T 细胞。
CD4+ T cell help is essential for primary CD8+ T cell responses to noninflammatory Ags. IL-2 is one of the principal cytokines made by naive CD4+ T cells, and we show in this study that it is an essential component of help. Adoptively transferred naive CD4+ TCR-transgenic OT-II cells supported endogenous primary CD8+ T cell responses, but IL-2-deficient OT-II cells were unable to provide help, although they responded to Ag in vivo and up-regulated CD40 ligand in vitro. Wild -type OT-II cells helped endogenous CD8+ T cell responses in IL-2-deficient mice, but not in IL-2Rα-deficient mice. Thus, CD4+ T cell-derived IL-2 is essential for CD8+ T cell responses to noninflammatory, cell-associated Ags. We suggest that it is also a critical component of help for CD8+ T cell responses to pathogens, because protective memory also requires CD8+ T cell stimulation by IL-2 during priming.
影响因子：
32.4
作者：
WILLERFORD, DM;CHEN, JZ;ALT, FW
通讯作者：
ALT, FW