Low frequency electrical waves in ensembles of proteinoid microspheres.

Low frequency electrical waves in ensembles of proteinoid microspheres.
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蛋白质微球集合中的低频电波。

DOI:
10.1038/s41598-023-29067-0
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发表时间:
2023-02-03
期刊:
影响因子:
4.6
通讯作者:
Adamatzky A
Adamatzky A
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Mougkogiannis P;Adamatzky A

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类蛋白(热蛋白)是通过将氨基酸加热至熔点并引发聚合以产生聚合链而产生的。氨基酸样分子或类蛋白可以在高温下凝结,形成称为类蛋白微球的聚集结构,据报道这种结构表现出强烈的电振荡。当氨基酸 L-谷氨酸 (L-Glu) 和 L-天冬氨酸 (L-Asp) 与不同频率和强度的电场结合时,就会产生电活动。我们通过一对差分电极记录了类蛋白微球整体的电活动。这类似于生理学中的细胞外记录或神经科学中的脑电图,但只是在微观层面上。我们发现这些信号群会产生电位尖峰,每个尖峰的平均持续时间为 26 分钟,平均幅度为 1 mV。尖峰通常以两个尖峰为一组进行分组。整体的电活动可以通过外部刺激来调节,因为类蛋白微球的整体在暴露于电场时可以产生并传播电活动。
Proteinoids (thermal proteins) are produced by heating amino acids to their melting point and initiation of polymerisation to produce polymeric chains. Amino acid-like molecules, or proteinoids, can condense at high temperatures to create aggregation structures called proteinoid microspheres, which have been reported to exhibit strong electrical oscillations. When the amino acids L-glutamic acid (L-Glu) and L-aspartic acid (L-Asp) were combined with electric fields of varying frequencies and intensities, electrical activity resulted. We recorded electrical activity of the proteinoid microspheres’ ensembles via a pair of differential electrodes. This is analogous to extracellular recording in physiology or EEG in neuroscience but at micro-level. We discovered that the ensembles produce spikes of electrical potential, an average duration of each spike is 26 min and average amplitude is 1 mV. The spikes are typically grouped in trains of two spikes. The electrical activity of the ensembles can be tuned by external stimulation because ensembles of proteinoid microspheres can generate and propagate electrical activity when exposed to electric fields.
DOI: 10.1038/s41467-021-25530-6
发表时间: 2021-09-24
影响因子: 16.6
作者:
Matsuo M;Kurihara K
通讯作者: Kurihara K
DOI: 10.1023/a:1018565428355
发表时间: 1997-08-15
期刊: JOURNAL OF MATERIALS SCIENCE LETTERS
影响因子: --
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影响因子: 1.6
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发表时间: 2007-07-01
期刊: BIOTECHNIQUES
影响因子: 2.7
作者:
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通讯作者: Collins, Tony J.