Alcohol use and interoception - A narrative review.
Alcohol use and interoception - A narrative review.
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DOI：
10.1016/j.pnpbp.2021.110397
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发表时间：
2021-12-20
影响因子：
5.6
通讯作者：
Kopera M
中科院分区：
文献类型：
--
作者：
Wiśniewski P;Maurage P;Jakubczyk A;Trucco EM;Suszek H;Kopera M
内感受被定义为感知和解释身体信号的能力，可能在酒精使用障碍（AUD）中发挥重要作用。早期研究表明内感受障碍与已知的 AUD 危险因素（例如述情障碍、情绪失调、冲动、疼痛）之间存在关联。神经生物学研究表明，酒精的神经毒性会在结构和功能水平上影响内感受系统（尤其是岛叶）的各个要素，并产生不同的短期/长期影响。相反，原发性内感受障碍可能会促进饮酒并促进成瘾的发展。尽管有令人信服的证据表明内感受障碍可能是 AUD 发生和病程的重要因素，但只有少数研究直接评估了 AUD 的内感受能力。研究表明，AUD 个体的内感受准确性（内感受的客观组成部分）较低，并且与渴望和情绪失调相关。与健康对照相比，AUD 个体的内感受敏感性更高。此外，有证据表明，在成瘾治疗中，专注于提高感知身体信号的能力的疗法是有效的。然而，内感受测量中仍然存在重要的方法学局限性，因此有必要进一步研究内感受与 AUD 之间的关联。
Interoception, defined as the ability to perceive and interpret body signals, may play an important role in alcohol use disorder (AUD). Earlier studies suggested an association between interoception impairment and known risk factors for AUD (e.g., alexithymia, emotion dysregulation, impulsivity, pain). Neurobiological studies show that the neurotoxicity of alcohol affects various elements of the interoceptive system (especially the insula) at structural and functional levels, with differential short/long term impacts. Conversely, primary interoceptive impairments may promote alcohol consumption and foster the evolution towards addiction. Despite convincing evidence demonstrating that interoception impairment may be an important contributor to the development and course of AUD, only a few studies directly evaluated interoceptive abilities in AUD. The research shows that interoceptive accuracy, the objective component of interoception, is lower in AUD individuals, and is correlated with craving and emotion dysregulation. Interoceptive sensibility is in turn higher in AUD individuals compared to healthy controls. Moreover, there is evidence that therapy focused on improving the ability to sense signals from the body in addiction treatment is effective. However, important methodological limitations in interoceptive measures persist, and it is therefore necessary to further investigate the associations between interoception and AUD.
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