Association between oxidative stress and atrial fibrillation.
Association between oxidative stress and atrial fibrillation.
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DOI：
10.1016/j.hrthm.2017.07.028
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发表时间：
2017-12
期刊：
影响因子：
5.5
通讯作者：
Quyyumi AA
中科院分区：
文献类型：
--
作者：
Samman Tahhan A;Sandesara PB;Hayek SS;Alkhoder A;Chivukula K;Hammadah M;Mohamed-Kelli H;O'Neal WT;Topel M;Ghasemzadeh N;Ko YA;Aida H;Gafeer M;Sperling L;Vaccarino V;Liang Y;Jones DP;Quyyumi AA
在实验研究中，氧化应激（OS）可能是房颤（AF）发生的关键机制，但人体数据仍然有限。全身OS可通过测量氨基硫醇（包括谷胱甘肽、半胱氨酸及其氧化产物）的循环水平来估计。我们检验了谷胱甘肽（EhGSH）和半胱氨酸的氧化还原电位与房颤的发生和流行有关的假设。在1439例接受冠状动脉造影的患者中，（10.3%）被诊断为房颤。在中位随访6.3年后，917例患者中的104例（11.5%）多变量逻辑回归和考克斯回归模型用于确定OS标志物是否是发生AF的独立预测因子。在调整传统危险因素、心力衰竭、冠状动脉疾病和高敏C反应蛋白水平后，EhGSH每增加10%，AF患病率增加30%（比值比[OR] 1.3; 95%置信区间[CI] 1.1-1.7; P = 0.02），当中位数用作临界值时，AF患病率增加90%（OR 1.9; 95% CI 1.3-2.7; P = 0.004）。EhGSH水平高于中位数对慢性AF的预测性（OR 4.0; 95% CI 1.3- 12.9; P = .01）高于阵发性AF（OR 1.7; 95% CI 1.1-2.7; P = .03）。EhGSH水平每增加10%，房颤发生风险增加40%（风险比1.4; 95%CI 1.1- 1.7; P = 0.01）。通过谷胱甘肽的氧化还原电位测量的OS增加与普遍的和偶发的AF相关。需要研究调节OS的疗法来治疗和预防AF。
Oxidative stress (OS) may be a key mechanism underlying the development of atrial fibrillation (AF) in experimental studies, but data in humans remain limited. Systemic OS can be estimated by measurements of circulating levels of the aminothiols including glutathione, cysteine, and their oxidized products. We tested the hypothesis that the redox potentials of glutathione (EhGSH) and cysteine will be associated with prevalent and incident AF. Plasma levels of aminothiols were measured in 1439 patients undergoing coronary angiography, of whom 148 (10.3%) had a diagnosis of AF. After a median follow-up of 6.3 years, 104 of 917 patients (11.5%) developed incident AF. Multivariate logistic regression and Cox regression models were used to determine whether OS markers were independent predictors of prevalent and incident AF after adjustment for traditional risk factors, heart failure, coronary artery disease, and high-sensitivity C-reactive protein level. For each 10% increase in EhGSH, the odds of prevalent AF was 30% higher (odds ratio [OR] 1.3; 95% confidence interval [CI] 1.1–1.7; P = .02) and 90% higher (OR 1.9; 95% CI 1.3–2.7; P = .004) when the median was used as a cutoff. The EhGSH level above the median was more predictive of chronic AF (OR 4.0; 95% CI 1.3– 12.9; P = .01) than of paroxysmal AF (OR 1.7; 95% CI 1.1–2.7; P = .03). Each 10% increase in EhGSH level was associated with a 40% increase in the risk of incident AF (hazard ratio 1.4; 95% CI 1.1– 1.7; P = .01). Increased OS measured by the redox potentials of glutathione is associated with prevalent and incident AF. Therapies that modulate OS need to be investigated to treat and prevent AF.
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影响因子：
37.8
作者：
Patel RS;Ghasemzadeh N;Eapen DJ;Sher S;Arshad S;Ko YA;Veledar E;Samady H;Zafari AM;Sperling L;Vaccarino V;Jones DP;Quyyumi AA
通讯作者：
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影响因子：
5.5
作者：
Li, Jie;Solus, Joseph;Chen, Qingxia;Rho, Young Hee;Milne, Ginger;Stein, C. Michael;Darbar, Dawood
通讯作者：
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影响因子：
37.8
作者：
Aviles, RJ;Martin, DO;Chung, MK
通讯作者：
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