Eyeblink Conditioning in Schizophrenia: A Critical Review.
Eyeblink Conditioning in Schizophrenia: A Critical Review.
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DOI：
10.3389/fpsyt.2015.00146
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发表时间：
2015
影响因子：
4.7
通讯作者：
Hetrick WP
中科院分区：
文献类型：
--
作者：
Kent JS;Bolbecker AR;O'Donnell BF;Hetrick WP
越来越多的证据表明精神分裂症患者存在小脑异常。认知障碍理论认为小脑功能障碍是精神分裂症的一个重要组成部分。延迟眨眼条件反射（EBC）是小脑依赖的翻译探针，是小脑完整性的行为指标。非人类动物研究已经很好地描述了EBC背后的回路，揭示了小脑是这项任务所体现的联想学习的基本回路。然而，精神分裂症的EBC结果一直不一致。本文全面回顾了已发表的有关精神分裂症患者EBC的研究，重点介绍了抗精神病药物、刺激和分析参数对精神分裂症患者EBC表现的可能影响。结果表明，精神分裂症患者的EBC表现受损是一致的，这是通过条件反射率下降来衡量的，并且药物或研究设计混淆不能解释这种损害。结果在精神分裂症的理论和神经化学模型的背景下进行讨论。
There is accruing evidence of cerebellar abnormalities in schizophrenia. The theory of cognitive dysmetria considers cerebellar dysfunction a key component of schizophrenia. Delay eyeblink conditioning (EBC), a cerebellar-dependent translational probe, is a behavioral index of cerebellar integrity. The circuitry underlying EBC has been well characterized by non-human animal research, revealing the cerebellum as the essential circuitry for the associative learning instantiated by this task. However, there have been persistent inconsistencies in EBC findings in schizophrenia. This article thoroughly reviews published studies investigating EBC in schizophrenia, with an emphasis on possible effects of antipsychotic medication and stimulus and analysis parameters on reports of EBC performance in schizophrenia. Results indicate a consistent finding of impaired EBC performance in schizophrenia, as measured by decreased rates of conditioning, and that medication or study design confounds do not account for this impairment. Results are discussed within the context of theoretical and neurochemical models of schizophrenia.
影响因子：
2.7
作者：
Park KM;Kim JJ;Seok JH;Chun JW;Park HJ;Lee JD
通讯作者：
Lee JD