Anhedonia and ambivalence in schizophrenic patients with fronto-cerebellar metabolic abnormalities: a fluoro-d-glucose positron emission tomography study.
Anhedonia and ambivalence in schizophrenic patients with fronto-cerebellar metabolic abnormalities: a fluoro-d-glucose positron emission tomography study.
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DOI：
10.4306/pi.2009.6.2.72
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发表时间：
2009-06
影响因子：
2.7
通讯作者：
Lee JD
中科院分区：
文献类型：
--
作者：
Park KM;Kim JJ;Seok JH;Chun JW;Park HJ;Lee JD
前额叶和小脑异常与精神分裂症患者较高的认知缺陷有关。目前的研究旨在表明患有额小脑功能异常的精神分裂症患者是否表现出更多的快感缺乏或矛盾心理。使用氟- d -葡萄糖正电子发射断层扫描测量了24名慢性精神分裂症患者和22名健康正常人的脑区域代谢活动。对每例患者是否存在区域性前额叶功能减退和区域性小脑功能亢进进行了调查。根据区域功能障碍的存在与否对患者进行亚组间的人口学和临床变量（包括情绪自我报告量表）进行比较。每例患者与全部正常对照的比较显示，24例患者中有14例具有区域额下功能，而11例具有区域小脑高功能。有前额叶功能减退的患者比无前额叶功能减退的患者表现出更严重的快感缺乏症，而小脑功能亢进的患者比无小脑功能亢进的患者表现出更严重的矛盾心理。似乎额小脑异常可能与精神分裂症的主要情绪特征有关，如快感缺乏和矛盾心理。
Prefrontal and cerebellar abnormalities have been associated with higher cognitive deficits in schizophrenia. The current study aimed to show whether or not schizophrenic patients with fronto-cerebellar functional abnormalities show more anhedonia or ambivalence. Regional cerebral metabolic activity was measured using fluoro-D-glucose positron emission tomography and was compared between 24 patients with chronic schizophrenia and 22 healthy normal volunteers. The existence of regional prefrontal hypofunction and regional cerebellar hyperfunction was investigated in each patient. Demographic and clinical variables including the emotional self-report scales were compared between the subgroups of the patients categorized according to the existence and the absence of the regional dysfunctions. Comparisons between each patient and the total normal controls revealed that 14 of the total twenty-four patients had regional hypofrontal functions, whereas 11 patients had regional hypercerebellar functions. Patients with prefrontal hypofunction showed more severe anhedonia than those without prefrontal hypofunction, whereas patients with cerebellar hyperfunction compared to those without cerebellar hyperfunction had more severe ambivalence. It seems that fronto-cerebellar abnormalities may be associated with cardinal emotional features of schizophrenia, such as anhedonia and ambivalence.
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