Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas
Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas
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子宫平滑肌瘤中 HMGIC 基因上游的易位断点表明该基因通过与脂肪瘤不同的机制发生失调
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
C. Morton
中科院分区：
文献类型：
--
作者：
M. Fejzo;H. Ashar;K. Krauter;W. Powell;M. Rein;S. Weremowicz;S. Yoon;R. Kucherlapati;K. Chada;C. Morton
子宫平滑肌瘤是女性最常见的盆腔肿瘤，在美国每年有超过20万例子宫切除术。q14-q15带中12号染色体的重排是子宫平滑肌瘤和其他良性间叶肿瘤的特征，我们在子宫平滑肌瘤、肺软骨样错构瘤和脂肪瘤中发现了跨越12号染色体易位断点的酵母人工染色体（YAC）。最近，我们证明，HMGIC，这是一个建筑因子映射内的YAC，被破坏脂肪瘤，导致新的融合转录。在这里，我们报告的定位易位断点在7子宫肌瘤从10至> 100 kb上游的HMGIC使用荧光原位杂交。我们的研究结果提示子宫平滑肌瘤和脂肪瘤有不同的病理生物学机制。HMGIC是第一个在子宫平滑肌瘤染色体重排中发现的基因，对于了解良性间充质增殖和分化具有重要意义。Genes Chromosom Cancer 17：1-6（1996）.© 1996 Wiley利斯公司
Uterine leiomyomata are the most common pelvic tumors in women and are the indication for more than 200,000 hysterectomies annually in the United States. Rearrangement of chromosome 12 in bands q14‐q15 is characteristic of uterine leiomyomata and other benign mesenchymal tumors, and we identified a yeast artificial chromosome (YAC) spanning chromosome 12 translocation breakpoints in a uterine leiomyoma, a pulmonary chondroid hamartoma, and a lipoma. Recently, we demonstrated that HMGIC, which is an architectural factor mapping within the YAC, is disrupted in lipomas, resulting in novel fusion transcripts. Here, we report on the localization of translocation breakpoints in seven uterine leiomyomata from 10 to > 100 kb upstream of HMGIC by use of fluorescence in situ hybridization. Our findings suggest a different pathobiologic mechanism in uterine leiomyomata from that in lipomas. HMGIC is the first gene identified in chromosomal rearrangements in uterine leiomyomata and has important implications for an understanding of benign mesenchymal proliferation and differentiation. Genes Chromosom Cancer 17:1–6 (1996). © 1996 Wiley‐Liss, Inc.
109 个脂肪瘤的细胞遗传学特征。
影响因子：
11.2
作者：
Sreekantaiah,C;Leong,SP;Karakousis,CP;McGee,DL;Rappaport,WD;Villar,HV;Neal,D;Fleming,S;Wankel,A;Herrington,PN
通讯作者：
Herrington,PN
7q22 的易位定义了子宫平滑肌瘤的关键区域。
影响因子：
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作者：
Sargent,MS;Weremowicz,S;Rein,MS;Morton,CC
通讯作者：
Morton,CC
迷你小鼠：转基因插入突变体中侏儒位点的破坏。
DOI：
10.1126/science.2305264
发表时间：
1990
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Xiang,X;Benson,KF;Chada,K
通讯作者：
Chada,K