Effects of Hydrocortisone and β-Aminopropionitrile on Stress-Strain and Stress-Relaxation Behaviors, and Birefringent Retardation of Collagen Fibers in the Rat Incisor Periodontal Ligament
Effects of Hydrocortisone and β-Aminopropionitrile on Stress-Strain and Stress-Relaxation Behaviors, and Birefringent Retardation of Collagen Fibers in the Rat Incisor Periodontal Ligament
复制标题
氢化可的松和β-氨基丙腈对大鼠切牙牙周膜应力应变和应力松弛行为以及胶原纤维双折射延迟的影响
DOI：
10.1080/03008200290001311
复制
发表时间：
2002
影响因子：
2.9
通讯作者：
M. Chiba
中科院分区：
文献类型：
--
作者：
K. Komatsu;M. Kanazashi;T. Arai;M. Chiba
三组雄性 Wistar 大鼠每天皮下注射 10 mg/kg 氢化可的松（HC 组）、300 mg/kg g-氨基丙腈（BAPN 组）或生理盐水（对照组），持续 10 天。在解剖下颌骨的横截面中检查切牙牙周膜的剪切应力-应变和应力-松弛特性。使用氢化可的松后，最大剪切应力和失效应变能密度均显着增加。施用 BAPN 后最大剪切应力降低。然而，最初 10 分钟的压力松弛在三组之间没有显示出显着差异。偏光显微镜分析显示，骨相关区域胶原纤维的延迟值在HC组中最高，在BAPN组中最低，但在牙齿相关区域和韧带中部区域则不然。表明氢化可的松或 BAPN 引起的变化主要发生在弹性成分中，少量发生在粘性成分中，尽管物理和生物力学特性是由所有不同成分的相互作用决定的。我们还认为，对药物的主要反应发生在韧带骨相关区域的胶原纤维中。
Three groups of male Wistar rats received daily subcutaneous injections of 10 mg/kg of hydrocortisone (HC group), 300 mg/kg of g -aminopropionitrile (BAPN group), or saline (control group), for 10 days. The shear stress-strain and stress-relaxation properties of the incisor periodontal ligament were examined in transverse sections from dissected mandibles. Both the maximum shear stress and failure strain energy density increased significantly following the administration of hydrocortisone. The maximum shear stress decreased following the administration of BAPN. However, the stress-relaxations in the initial 10 min did not show significant differences among the three groups. Polarized light microscopic analysis revealed that the retardation value of the collagen fibers was highest in the HC group and lowest in the BAPN group for the bone-related area, but not for the tooth-related and middle areas of the ligament. It is suggested that the changes induced by hydrocortisone or BAPN occurred mainly in the elastic components and to a minor extent in the viscous components although the physical and biomechanical properties are determined by the interaction of all the various components. We also suggest that the main response to the drugs occurred in the collagen fibers in the bone-related area of the ligament.
登录
查看更多内容
影响因子：
2.9
作者：
M. Yamauchi;E. P. Katz;E. P. Katz;G. Mechanic
通讯作者：
M. Yamauchi;E. P. Katz;E. P. Katz;G. Mechanic
影响因子：
15.9
作者：
CLARK, SD;KOBAYASHI, DK;WELGUS, HG
通讯作者：
WELGUS, HG
糖皮质激素和胶原蛋白合成：体内和细胞培养研究的比较。
DOI：
10.1016/s0174-173x(81)80037-4
发表时间：
1981
期刊：
Collagen and related research
影响因子：
--
作者：
Cutroneo,KR;Rokowski,R;Counts,DF
通讯作者：
Counts,DF
β-氨基丙腈对牙周膜的影响。
影响因子：
3.5
作者：
Cho,MI;Garant,PR
通讯作者：
Garant,PR