The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily.
The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily.
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DOI：
10.3390/vaccines6040076
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发表时间：
2018-11-20
期刊：
影响因子：
7.8
通讯作者：
Spencer JD
中科院分区：
文献类型：
--
作者：
Schwartz L;Cohen A;Thomas J;Spencer JD
核糖核酸酶A超家族由免疫细胞和上皮组织分泌的阳离子肽组成。虽然它们的生理作用尚不清楚，但脊椎动物核糖核酸酶A超家族的几个成员表现出抗微生物和免疫调节活性。本综述的目的是提供一个概述的核糖核酸酶A超家族的已发表的文献，强调每个肽的调节，抗菌性能和免疫调节功能。随着关于这些核糖核酸酶根除入侵病原体和调节免疫功能的机制的更多见解的出现，这些核糖核酸酶可能有潜力被开发为用于某些人类疾病的新型疗法。
The Ribonuclease A Superfamily is composed of cationic peptides that are secreted by immune cells and epithelial tissues. Although their physiological roles are unclear, several members of the vertebrate Ribonuclease A Superfamily demonstrate antimicrobial and immune modulation activities. The objective of this review is to provide an overview of the published literature on the Ribonuclease A Superfamily with an emphasis on each peptide’s regulation, antimicrobial properties, and immunomodulatory functions. As additional insights emerge regarding the mechanisms in which these ribonucleases eradicate invading pathogens and modulate immune function, these ribonucleases may have the potential to be developed as a novel class of therapeutics for some human diseases.
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