Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study.
Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study.
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在基于人群的COLAUS研究中，高脑结构血症与蛋白尿独立相关。
DOI：
10.1186/1471-2458-11-733
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发表时间：
2011-09-26
影响因子：
4.5
通讯作者：
Bochud M
中科院分区：
文献类型：
--
作者：
Marti F;Vollenweider P;Marques-Vidal PM;Mooser V;Waeber G;Paccaud F;Bochud M
血清同型半胱氨酸和尿酸水平升高均与心血管风险相关。我们分析了同型半胱氨酸和尿酸是否与肾小球滤过率（GFR）和蛋白尿相互独立相关。我们还研究了与同型半胱氨酸相关的MTHFR多态性与白蛋白尿的关系，以进一步了解因果关系。这是一项在白人中进行的基于人群的横断面研究（n = 5913）。高同型半胱氨酸血症定义为血清总同型半胱氨酸≥ 15 μmol/L。白蛋白尿定义为尿白蛋白/肌酐比值> 30 mg/g。尿酸与同型半胱氨酸呈正相关（男性r = 0.246，女性r = 0.287，P < 0.001）。随着同型半胱氨酸水平的增加，白蛋白尿的患病率也增加（GFR正常的受试者从6.4%增加到17.3%，GFR降低的受试者从3.5%增加到14.5%，趋势P < 0.005）。高同型半胱氨酸血症（OR = 2.22，95%可信区间：1.60-3.08，P < 0.001）和血尿酸升高（OR = 1.27，1.08-1.50，P = 0.004）与蛋白尿显著相关，与高血压和2型糖尿病无关。与高同型半胱氨酸血症相关的白蛋白尿风险增加2倍，与高血压或糖尿病相关的风险相似。与高同型半胱氨酸相关的MTHFR等位基因与蛋白尿风险增加相关。在一般成人人群中，血清同型半胱氨酸和尿酸升高与白蛋白尿相关，两者相互独立，且与肾功能无关。
Increased serum levels of homocysteine and uric acid have each been associated with cardiovascular risk. We analyzed whether homocysteine and uric acid were associated with glomerular filtration rate (GFR) and albuminuria independently of each other. We also investigated the association of MTHFR polymorphisms related to homocysteine with albuminuria to get further insight into causality. This was a cross-sectional population-based study in Caucasians (n = 5913). Hyperhomocysteinemia was defined as total serum homocysteine ≥ 15 μmol/L. Albuminuria was defined as urinary albumin-to-creatinine ratio > 30 mg/g. Uric acid was associated positively with homocysteine (r = 0.246 in men and r = 0.287 in women, P < 0.001). The prevalence of albuminuria increased across increasing homocysteine categories (from 6.4% to 17.3% in subjects with normal GFR and from 3.5% to 14.5% in those with reduced GFR, P for trend < 0.005). Hyperhomocysteinemia (OR = 2.22, 95% confidence interval: 1.60-3.08, P < 0.001) and elevated serum uric acid (OR = 1.27, 1.08-1.50, per 100 μmol/L, P = 0.004) were significantly associated with albuminuria, independently of hypertension and type 2 diabetes. The 2-fold higher risk of albuminuria associated with hyperhomocysteinemia was similar to the risk associated with hypertension or diabetes. MTHFR alleles related to higher homocysteine were associated with increased risk of albuminuria. In the general adult population, elevated serum homocysteine and uric acid were associated with albuminuria independently of each other and of renal function.
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COLAUS研究：一项基于人群的研究，旨在研究心血管危险因素和代谢综合征的流行病学和遗传决定因素。
影响因子：
2.1
作者：
Firmann, Mathieu;Mayor, Vladimir;Vidal, Pedro Marques;Bochud, Murielle;Pecoud, Alain;Hayoz, Daniel;Paccaud, Fred;Preisig, Martin;Song, Kijoung S.;Yuan, Xin;Danoff, Theodore M.;Stirnadel, Heide A.;Waterworth, Dawn;Mooser, Vincent;Waeber, Gerard;Vollenweider, Peter
通讯作者：
Vollenweider, Peter
影响因子：
13.2
作者：
Jamison, Rex L.;Shih, Mei-Chiung;Lavori, Philip
通讯作者：
Lavori, Philip
影响因子：
6.1
作者：
Boeger, Carsten A.;Stubanus, Mike;Kraemer, Bernhard K.
通讯作者：
Kraemer, Bernhard K.
DOI：
10.1034/j.1600-0412.2001.080009803.x
发表时间：
2001-09-01
影响因子：
4.3
作者：
Lauszus, FF;Gron, PL;Klebe, JG
通讯作者：
Klebe, JG
影响因子：
30.8
作者：
Loos, Ruth J. F.;Lindgren, Cecilia M.;Li, Shengxu;Wheeler, Eleanor;Zhao, Jing Hua;Prokopenko, Inga;Inouye, Michael;Freathy, Rachel M.;Attwood, Antony P.;Beckmann, Jacques S.;Berndt, Sonja I.;Bergmann, Sven;Bennett, Amanda J.;Bingham, Sheila A.;Bochud, Murielle;Brown, Morris;Cauchi, Stephane;Connell, John M.;Cooper, Cyrus;Smith, George Davey;Day, Ian;Dina, Christian;De, Subhajyoti;Dermitzakis, Emmanouil T.;Doney, Alex S. F.;Elliott, Katherine S.;Elliott, Paul;Evans, David M.;Farooqi, I. Sadaf;Froguel, Philippe;Ghori, Jilur;Groves, Christopher J.;Gwilliam, Rhian;Hadley, David;Hall, Alistair S.;Hattersley, Andrew T.;Hebebrand, Johannes;Heid, Iris M.;Herrera, Blanca;Hinney, Anke;Hunt, Sarah E.;Jarvelin, Marjo-Riitta;Johnson, Toby;Jolley, Jennifer D. M.;Karpe, Fredrik;Keniry, Andrew;Khaw, Kay-Tee;Luben, Robert N.;Mangino, Massimo;Marchini, Jonathan;McArdle, Wendy L.;McGinnis, Ralph;Meyre, David;Munroe, Patricia B.;Morris, Andrew D.;Ness, Andrew R.;Neville, Matthew J.;Nica, Alexandra C.;Ong, Ken K.;O'Rahilly, Stephen;Owen, Katharine R.;Palmer, Colin N. A.;Papadakis, Konstantinos;Potter, Simon;Pouta, Anneli;Qi, Lu;Randall, Joshua C.;Rayner, Nigel W.;Ring, Susan M.;Sandhu, Manjinder S.;Scherag, Andre;Sims, Matthew A.;Song, Kijoung;Soranzo, Nicole;Speliotes, Elizabeth K.;Syddall, Holly E.;Teichmann, Sarah A.;Timpson, Nicholas J.;Tobias, Jonathan H.;Uda, Manuela;Vogel, Carla I. Ganz;Wallace, Chris;Waterworth, Dawn M.;Weedon, Michael N.;Willer, Cristen J.;Wraight, Vicki L.;Yuan, Xin;Zeggini, Eleftheria;Hirschhorn, Joel N.;Strachan, David P.;Ouwehand, Willem H.;Caulfield, Mark J.;Samani, Nilesh J.;Frayling, Timothy M.;Vollenweider, Peter;Waeber, Gerard;Mooser, Vincent;Deloukas, Panos;McCarthy, Mark I.;Wareham, Nicholas J.;Barroso, Ines
通讯作者：
Barroso, Ines