The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome.
The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome.
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COLAUS研究：一项基于人群的研究，旨在研究心血管危险因素和代谢综合征的流行病学和遗传决定因素。
DOI：
10.1186/1471-2261-8-6
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发表时间：
2008-03-17
影响因子：
2.1
通讯作者：
Vollenweider, Peter
中科院分区：
文献类型：
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作者：
Firmann, Mathieu;Mayor, Vladimir;Vidal, Pedro Marques;Bochud, Murielle;Pecoud, Alain;Hayoz, Daniel;Paccaud, Fred;Preisig, Martin;Song, Kijoung S.;Yuan, Xin;Danoff, Theodore M.;Stirnadel, Heide A.;Waterworth, Dawn;Mooser, Vincent;Waeber, Gerard;Vollenweider, Peter
心血管疾病及其相关风险因素仍然是西方社会死亡的主要原因。为了评估瑞士洛桑白人人群中心血管风险因素（CVRF）的患病率，我们进行了一项基于人群的研究（Colaus研究）。CoLaus研究的次要目的是确定与CVRF相关的新遗传决定因素。单中心、横断面研究，包括随机抽样的6，188名广泛表型分析的高加索受试者（3，251名女性和2，937名男性），年龄在35至75岁之间，居住在洛桑，并使用500 K Affyssin芯片技术进行基因分型。肥胖（体重指数≥ 30 kg/m2）、吸烟、高血压（血压≥ 140/90 mmHg和/或治疗），血脂异常（高LDL-胆固醇和/或低HDL-胆固醇和/或高甘油三酯水平）和糖尿病（空腹血糖≥ 7 mmol/l和/或治疗）（15.7%）、1673例（27.0%）、2268例（36.7%）、2113例（34.2%）和407例（6.6%），男性患病率高于女性。在男女两性中，肥胖、高血压和糖尿病的患病率随着年龄的增长而增加。洛桑人群中主要CVRF的患病率较高，尤其是男性。我们预计，鉴于其规模，表型分析的深度和密集的全基因组遗传数据的可用性，CoLaus研究将成为一个独特的资源，不仅可以调查孤立或聚集的CVRF（如代谢综合征）的流行病学，而且还可以作为一个发现集和复制集，以确定与这些疾病相关的新基因。
Cardiovascular diseases and their associated risk factors remain the main cause of mortality in western societies. In order to assess the prevalence of cardiovascular risk factors (CVRFs) in the Caucasian population of Lausanne, Switzerland, we conducted a population-based study (Colaus Study). A secondary aim of the CoLaus study will be to determine new genetic determinants associated with CVRFs. Single-center, cross-sectional study including a random sample of 6,188 extensively phenotyped Caucasian subjects (3,251 women and 2,937 men) aged 35 to 75 years living in Lausanne, and genotyped using the 500 K Affymetrix chip technology. Obesity (body mass index ≥ 30 kg/m2), smoking, hypertension (blood pressure ≥ 140/90 mmHg and/or treatment), dyslipidemia (high LDL-cholesterol and/or low HDL-cholesterol and/or high triglyceride levels) and diabetes (fasting plasma glucose ≥ 7 mmol/l and/or treatment) were present in 947 (15.7%), 1673 (27.0%), 2268 (36.7%), 2113 (34.2%) and 407 (6.6%) of the participants, respectively, and the prevalence was higher in men than in women. In both genders, the prevalence of obesity, hypertension and diabetes increased with age. The prevalence of major CVRFs is high in the Lausanne population in particular in men. We anticipate that given its size, the depth of the phenotypic analysis and the availability of dense genome-wide genetic data, the CoLaus Study will be a unique resource to investigate not only the epidemiology of isolated, or aggregated CVRFs like the metabolic syndrome, but can also serve as a discovery set, as well as replication set, to identify novel genes associated with these conditions.
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影响因子：
--
作者：
LEAN, MEJ;HAN, TS;MORRISON, CE
通讯作者：
MORRISON, CE
影响因子：
16.2
作者：
Cowie, Catherine C.;Engelgau, Michael M.;Gregg, Edward W.
通讯作者：
Gregg, Edward W.
影响因子：
6
作者：
Nedeltchev, K;Arnold, M;Mattle, HP
通讯作者：
Mattle, HP
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
影响因子：
64.8
作者：
Chanock, Stephen J.;Manolio, Teri;Collins, Francis S.
通讯作者：
Collins, Francis S.