Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly.
Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly.
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DOI：
10.3389/fragi.2022.840827
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发表时间：
2022
影响因子：
--
通讯作者：
Pandiyan, Pushpa
中科院分区：
文献类型：
--
作者：
Shive, Carey;Pandiyan, Pushpa
最佳的免疫反应需要免疫系统的先天性和适应性臂之间适当的相互作用，以及激活和调节的适当平衡。经过几十年的生活，老化的免疫系统不断暴露于免疫应激源和炎症攻击下，导致免疫衰老。在这篇综述中，我们将讨论老年人的炎症，特别是 T 淋巴细胞中的 IL-6 和 IL-1b，以及炎症与死亡率和发病率（特别是心血管疾病和癌症）的关系。尽管许多研究表明抗炎细胞因子 TGF-b 在老年人中升高，但炎症仍然加剧。因此，免疫反应的调节和使免疫系统恢复稳态的能力也很重要。因此，我们将讨论衰老过程中的细胞变化，重点关注衰老过程中的衰老 T 细胞和 CD4+ CD25+ FOXP3+ 调节性 T 细胞 (Treg)
An optimal immune response requires the appropriate interaction between the innate and the adaptive arms of the immune system as well as a proper balance of activation and regulation. After decades of life, the aging immune system is continuously exposed to immune stressors and inflammatory assaults that lead to immune senescence. In this review, we will discuss inflammaging in the elderly, specifically concentrating on IL-6 and IL-1b in the context of T lymphocytes, and how inflammation is related to mortality and morbidities, specifically cardiovascular disease and cancer. Although a number of studies suggests that the anti-inflammatory cytokine TGF-b is elevated in the elderly, heightened inflammation persists. Thus, the regulation of the immune response and the ability to return the immune system to homeostasis is also important. Therefore, we will discuss cellular alterations in aging, concentrating on senescent T cells and CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) in aging
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影响因子：
8.8
作者：
Ahmed R;Miners KL;Lahoz-Beneytez J;Jones RE;Roger L;Baboonian C;Zhang Y;Wang ECY;Hellerstein MK;McCune JM;Baird DM;Price DA;Macallan DC;Asquith B;Ladell K
通讯作者：
Ladell K
影响因子：
4.7
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Bhaskaran N;Jayaraman S;Quigley C;Mamileti P;Ghannoum M;Weinberg A;Thuener J;Pan Q;Pandiyan P
通讯作者：
Pandiyan P
影响因子：
20.3
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通讯作者：
Koup, RA
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16.6
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通讯作者：
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影响因子：
7.8
作者：
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通讯作者：
de Magalhaes, Joao Pedro