The utility of the Hopkins Verbal Learning Test (Chinese version) for screening dementia and mild cognitive impairment in a Chinese population.
The utility of the Hopkins Verbal Learning Test (Chinese version) for screening dementia and mild cognitive impairment in a Chinese population.
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霍普金斯语言学习测试（中文版）在中国人群中筛查痴呆和轻度认知障碍的效用
DOI：
10.1186/1471-2377-12-136
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发表时间：
2012-11-07
期刊：
影响因子：
2.6
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Shi J;Tian J;Wei M;Miao Y;Wang Y
背景霍普金斯言语学习测验（HVLT）已被证实可用于检测英语人群中的痴呆。然而，目前还没有研究对HVLT量表的中文版进行检验，并且在中国人群中适用的痴呆临界值尚不清楚。方法在北京东直门医院记忆门诊招募631名60岁及以上的受试者。其中，249人被归类为表现出正常认知（NC），134人被诊断为轻度认知障碍（MCI），97人被诊断为阿尔茨海默病（AD），14人被诊断为血管性痴呆（VaD），50人被诊断为其他类型的痴呆，包括混合型痴呆。计算HVLT总学习分数，识别分数和总分数的判别能力，以确定其检测MCI，AD和其他痴呆症的敏感性和特异性，以及各种截止scores.ResultsHVLT分数受年龄，教育程度和性别的影响。HVLT总学习评分显示出灵敏度和特异性之间的最佳平衡，使用ROC曲线区分AD和其他类型的痴呆与NC的临界值为15.5，区分AD和所有类型的痴呆的灵敏度为94.7%，检测AD的特异性为92.5%，检测所有类型的痴呆的特异性为93.4%。我们将AD和MCI组按年龄分层，并计算每个年龄组的有效性。在50-64岁年龄组中，当临界值为18.5时，鉴别NC和AD的敏感性为0.955，特异性为0.921，在65-80岁年龄组中，当HVLT总回忆的临界值为21.5时，敏感度和特异度达到最佳平衡（69.1%和70.7%，分别）区分MCI从NC。ConclusionA截止分数为15.5的HVLT总的学习成绩导致痴呆和NC组之间的高辨别能力。这表明，HVLT总的学习成绩可以提供一个有用的工具，区分痴呆，但不是MCI，从NC在临床和流行病学实践。
BackgroundThe Hopkins Verbal Learning Test (HVLT) has been validated for detecting dementia in English-speaking populations. However, no studies have examined the Chinese version of the HVLT scale, and appropriate cut-off scores for dementia in the Chinese population remain unclear.Methods631 subjects aged 60 and over were recruited at a memory clinic at Dongzhimen Hospital in Beijing. Of these, 249 were classified as exhibiting normal cognition (NC), 134 were diagnosed with mild cognitive impairment (MCI), 97 were diagnosed with Alzheimer’s disease (AD), 14 met the diagnosis for vascular dementia (VaD), and 50 were diagnosed with other types of dementia, including mixed dementia. The discriminative capacity of the HVLT total learning score, recognition score and total score were calculated to determine their sensitivity and specificity for detecting MCI, AD and other dementias, and various cut-off scores.ResultsHVLT scores were affected by age, education and sex. The HVLT total learning score exhibited an optimal balance between sensitivity and specificity using a cut-off score of 15.5 for distinguishing AD and other types of dementia from NC using the ROC curve, with sensitivity of 94.7% for distinguishing AD and all types of dementia, and specificity of 92.5% for detecting AD and 93.4% for detecting all types of dementias. We stratified the AD and MCI groups by age, and calculated the validity in each age group. In the 50–64 years age group, when the cutoff score was 18.5, the sensitivity of 0.955 and specificity of 0.921 were obtained for discriminating the NC and AD groups, and in the 65–80 years group, and optimal sensitivity and specificity values (0.948 and 0.925, respectively) were obtained with a cutoff score of 14.5.When the cutoff score was 21.5 in HVLT total recall, an optimal balance was obtained between sensitivity and specificity (69.1% and 70.7%, respectively) in distinguishing MCI from NC.ConclusionA cut-off score of 15.5 in the HVLT total learning score led to high discriminative capacity between the dementia and NC groups. This suggests that the HVLT total learning score can provide a useful tool for discriminating dementia, but not MCI, from NC in clinical and epidemiological practice.
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影响因子：
158.5
作者：
Petersen, RC;Thomas, RG;Thal, LJ
通讯作者：
Thal, LJ
影响因子：
--
作者：
O'Bryant, Sid E.;Humphreys, Joy D.;Smith, Glenn E.;Ivnik, Robert J.;Graff-Radford, Neill R.;Petersen, Ronald C.;Lucas, John A.
通讯作者：
Lucas, John A.
影响因子：
168.9
作者：
Ferri, CP;Prince, M;Scazufca, M
通讯作者：
Scazufca, M
影响因子：
9.9
作者：
MCKHANN, G;DRACHMAN, D;STADLAN, EM
通讯作者：
STADLAN, EM
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR