Clinicopathological risk factors for recurrence after neoadjuvant chemotherapy and radical hysterectomy in cervical cancer.
Clinicopathological risk factors for recurrence after neoadjuvant chemotherapy and radical hysterectomy in cervical cancer.
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DOI：
10.1186/1477-7819-11-301
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发表时间：
2013-11-25
影响因子：
3.2
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Wang H;Zhu L;Lu W;Xu H;Yu Y;Yang Y
宫颈癌是常见的妇科恶性肿瘤之一，术后复发率高。本研究旨在分析宫颈癌手术治疗后复发的临床病理危险因素，为预防复发和改善预后提供依据。我们对1998年1月1日至2011年12月31日期间接受手术治疗的424例子宫颈癌病例进行回顾性研究，其中23例复发。通过单因素和多因素分析评价复发组和非复发组的相关复发危险因素。通过单因素分析，肿瘤分化、临床分期、盆腔淋巴结转移、术后放疗及术后化疗与宫颈癌复发相关。多因素COX模型分析显示盆腔淋巴结转移及术后化疗对复发率有影响。中、高分化肿瘤、临床分期晚期、盆腔淋巴结阳性提示宫颈癌复发率高。术后化疗和放疗可有效降低复发率。综上所述，宫颈淋巴结转移和术后化疗是宫颈癌根治术后复发的两个独立因素。
Cervical cancer is one of the common gynecological malignancies with a high recurrence rate after surgery. This study aimed to analyze the clinicopathological risk factors for recurrence after the surgical treatment of cervical cancer and provide the basis for the prevention of recurrence and an improvement of prognosis. A total of 424 cervical cancer cases between 1 January 1998 and 31 December 2011 undergoing surgical treatment were studied retrospectively, of which 23 cases had recurrences. Relevant recurrence risk factors were evaluated by univariate and multivariate analyses between recurrence group and non-recurrence group. Using univariate analysis, tumor differentiation, clinical stage, pelvic lymph node metastasis, postoperative radiotherapy and postoperative chemotherapy were related to recurrence of cervical cancer. Multivariate COX model analysis revealed that pelvic lymph node metastasis and postoperative chemotherapy had an impact on recurrence rate. Moderately and highly differentiated tumor, advanced clinical stage, and positive pelvic lymph nodes indicated a high recurrence rate of cervical cancer. Postoperative chemotherapy and radiotherapy can effectively reduce the recurrence rate. In conclusion, cervical lymph node metastasis and postoperative chemotherapy are two independent factors for recurrence of cervical cancer after radical surgery.
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影响因子：
45.3
作者：
Madersbacher, S;Hochreiter, W;Studer, UE
通讯作者：
Studer, UE
影响因子：
50.5
作者：
Lissoni, A. A.;Colombo, N.;Rulli, E.
通讯作者：
Rulli, E.
影响因子：
4.7
作者：
Yamakawa, Y;Fujimura, M;Saito, S
通讯作者：
Saito, S
影响因子：
2.1
作者：
Liu, M. -T.;Hsu, J. -C.;Chen, T. -H.
通讯作者：
Chen, T. -H.
影响因子：
4.7
作者：
Chen, Huijun;Liang, Chuan;Wu, Xufeng
通讯作者：
Wu, Xufeng