Th17/1-Biased Inflammatory Environment Involved in the Response of Epithelial Cells to Antigen Stimuli in Nasal Polyps.
Th17/1-Biased Inflammatory Environment Involved in the Response of Epithelial Cells to Antigen Stimuli in Nasal Polyps.
复制标题
鼻息肉中 Th17/1 偏向的炎症环境参与上皮细胞对抗原刺激的反应
DOI：
10.1155/2021/5531606
复制
发表时间：
2021
影响因子：
4.1
通讯作者：
Xiao L
中科院分区：
文献类型：
--
作者：
Xu G;Chen S;Dong Y;Xiao L
多项研究表明，鼻息肉(NPs)中IL-17A显著升高。然而，NPs中产生IL-17A的细胞的来源和特征尚不完全清楚。我们从NPs和钩状组织中分离出单个核细胞，并用流式细胞仪对其进行分析。结果表明，与钩状组织相比，NP组织中IL-17A的表达增加。NP组织中表达IL-17A的细胞主要为CD3+T细胞，包括Th17细胞、Tc17细胞和γδT17细胞。与钩状组织不同，大多数Th17细胞在NP组织中高表达干扰素-γ，如高表达CXCR3、CCR6、RoRγt和T-bet的Th17/1细胞。此外，偏向Th17/1的环境增强了鼻黏膜上皮细胞对细菌和病毒刺激的反应，这意味着Th17/1细胞在NPs的病理发展中比Th17或Th1细胞发挥更大的作用。
Several studies showed that IL-17A was significantly increased in nasal polyps (NPs). However, the source and characteristics of IL-17A-producing cells in NPs were not fully understood. We isolated mononuclear cells from NPs and uncinate tissues and analyzed them using flow cytometry. The results indicated that IL-17A was increased in NP tissues compared to uncinate tissues. The main IL-17A-expressing cells were CD3+ T cells in NP tissues, including Th17 cells, Tc17 cells, and γδT17 cells. Not similar to those in uncinate tissues, the majority of Th17 cells highly coexpressed IFN-γ in NP tissues, such as Th17/1 cells, which highly expressed CXCR3, CCR6, RORγt, and T-bet. Furthermore, Th17/1-biased environment increased the response of nasal epithelial cells to bacterial and viral stimuli, implying that Th17/1 cells play a greater role in the pathological development of NPs than Th17 or Th1 cells.
登录
查看更多内容
DOI：
10.1186/s13223-016-0123-3
发表时间：
2016
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
König K;Klemens C;Haack M;Nicoló MS;Becker S;Kramer MF;Gröger M
通讯作者：
Gröger M
鼻息肉中的人 IL-21( )IFN-gamma( )CD4( ) T 细胞受 IL-12 调节
影响因子：
4.6
作者：
Xiao L;Jia L;Zhang Y;Yu S;Wu X;Yang B;Li H;Wu C
通讯作者：
Wu C
Tc17/IL-17A通过NF-κB通路上调慢性鼻窦炎患者鼻上皮细胞MMP-9的表达
影响因子：
7.3
作者：
Chen X;Chang L;Li X;Huang J;Yang L;Lai X;Huang Z;Wang Z;Wu X;Zhao J;Bellanti JA;Zheng SG;Zhang G
通讯作者：
Zhang G
慢性鼻窦炎伴鼻息肉中 Th2 和 Th17 通路之间的串扰
影响因子：
14.2
作者：
Wang, Min;Zhang, Nan;Bachert, Claus
通讯作者：
Bachert, Claus
影响因子：
6.4
作者：
Wang, Weiqing;Gao, Yali;Lv, Wei
通讯作者：
Lv, Wei