Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study.
Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study.
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脑表面收缩映射在第一期精神分裂症中：一项纵向磁共振成像研究。
DOI：
10.1038/mp.2008.34
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发表时间：
2009-10
影响因子：
11
通讯作者：
中科院分区：
文献类型：
--
作者：
精神分裂症与大脑结构异常有关，但这些变化的发生时间和过程仍不清楚。纵向磁共振成像 (MRI) 研究表明，患者在发病前后和发病后脑体积会逐渐减少，但受影响的大脑区域存在相当大的差异。精神分裂症这些进行性变化的解剖学模式在很大程度上是未知的。在这项研究中，对 16 名精神分裂症患者和 14 名年龄匹配的健康受试者重复进行了 MRI 扫描，这些患者在首次发病后相隔约 2 年。皮质模式匹配与使用萎缩归一化的结构图像评估相结合，用于比较患者和对照组之间的皮质表面收缩率。与健康对照组相比，首发精神分裂症（FESZ）患者额叶背侧的表面收缩明显更大。总体而言，患者和健康对照组的大脑表面收缩表现出相似的解剖模式，前一组的大脑表面收缩在整个大脑表面的幅度被夸大了。精神分裂症早期病程中的结构变化模式与正常发育相关的结构变化模式如此密切，这与精神分裂症相关因素在精神分裂症病理生理学中与正常青少年大脑发育过程相互作用的假设是一致的。精神分裂症患者中观察到的夸张的进行性变化可能反映了突触修剪率的增加，导致神经元连接的过度丧失，正如该疾病的晚期神经发育假说所预测的那样。
Schizophrenia is associated with structural brain abnormalities, but the timing of onset and course of these changes remains unclear. Longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive brain volume decreases in patients around and after the onset of illness, although considerable discrepancies exist regarding which brain regions are affected. The anatomical pattern of these progressive changes in schizophrenia is largely unknown. In this study, MRI scans were acquired repeatedly from 16 schizophrenia patients approximately 2 years apart following their first episode of illness, and also from 14 age-matched healthy subjects. Cortical Pattern Matching, in combination with Structural Image Evaluation, using Normalisation, of Atrophy, was applied to compare the rates of cortical surface contraction between patients and controls. Surface contraction in the dorsal surfaces of the frontal lobe was significantly greater in patients with first-episode schizophrenia (FESZ) compared with healthy controls. Overall, brain surface contraction in patients and healthy controls showed similar anatomical patterns, with that of the former group exaggerated in magnitude across the entire brain surface. That the pattern of structural change in the early course of schizophrenia corresponds so closely to that associated with normal development is consistent with the hypothesis that a schizophrenia-related factor interacts with normal adolescent brain developmental processes in the pathophysiology of schizophrenia. The exaggerated progressive changes seen in patients with schizophrenia may reflect an increased rate of synaptic pruning, resulting in excessive loss of neuronal connectivity, as predicted by the late neurodevelopmental hypothesis of the illness.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
14.5
作者：
Nakamura, Motoaki;Nestor, Paul G.;Shenton, Martha E.
通讯作者：
Shenton, Martha E.
影响因子：
--
作者：
Lieberman, JA;Tollefson, GD;Tohen, M
通讯作者：
Tohen, M
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T