HMGB1 is associated with atherosclerotic plaque composition and burden in patients with stable coronary artery disease.
HMGB1 is associated with atherosclerotic plaque composition and burden in patients with stable coronary artery disease.
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DOI：
10.1371/journal.pone.0052081
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Korosoglou G
中科院分区：
文献类型：
--
作者：
Andrassy M;Volz HC;Maack B;Schuessler A;Gitsioudis G;Hofmann N;Laohachewin D;Wienbrandt AR;Kaya Z;Bierhaus A;Giannitsis E;Katus HA;Korosoglou G
炎症在动脉粥样硬化中的作用被广泛认识。高迁移率族蛋白1(HMGB1)是一种损伤相关的分子模式分子，作为炎症介质，最近被认为与动脉粥样硬化的发生有关。在这项研究中，我们试图调查可疑或已知冠心病(CAD)患者血浆HMGB1与冠状动脉斑块成分的关系。对152例临床诊断为稳定性冠心病的患者行256层冠状动脉CT血管造影(CCTA)，测定HMGB1、高敏肌钙蛋白T(HsTnT)和高敏C反应蛋白(HsCRP)。使用CCTA，我们评估了1)冠状动脉钙化，2)非钙化斑块负荷和3)非钙化斑块区域血管重构的存在。单因素分析显示，hsCRP、hsTnT、HMGB1以及年龄和动脉粥样硬化危险因素与非钙化斑块负荷相关(r = 0.21，p = 0.009；r = 0.48，p<；0.001；r = 0.34，p<；0.001)。多因素分析显示，hsTnT和HMGB1仍是非钙化斑块负荷的独立预测因素(r = 分别为0.48和0.34，p均为0.001)，而hs- = 的变化趋势不明显(r = 为0.21，p = 为0.07)。通过hsTnT和HMGB1的结合，在上三叉神经节患者中，这两个生物标志物对非钙化斑块和重塑斑块的存在都有很高的阳性预测值(分别为96%和77%)，分别超过了每个标志物的阳性预测值。除了hs-TnT这一公认的心血管危险标志物外，HMGB1与稳定性冠心病患者的非钙化斑块负荷独立相关，而hs-CRP的预测价值较低。Hs-TnT和HMGB1在预测复杂冠状动脉斑块方面具有互补价值。
The role of inflammation in atherosclerosis is widely appreciated. High mobility group box 1 (HMGB1), an injury-associated molecular pattern molecule acting as a mediator of inflammation, has recently been implicated in the development of atherosclerosis. In this study, we sought to investigate the association of plasma HMGB1 with coronary plaque composition in patients with suspected or known coronary artery disease (CAD). HMGB1, high sensitive troponin T (hsTnT) and high sensitive C-reactive protein (hsCRP) were determined in 152 consecutive patients with suspected or known stable CAD who underwent clinically indicated 256-slice coronary computed tomography angiography (CCTA). Using CCTA, we assessed 1) coronary calcification, 2) non-calcified plaque burden and 3) the presence of vascular remodeling in areas of non-calcified plaques. Using univariate analysis, hsCRP, hsTnT and HMGB1 as well as age, and atherogenic risk factors were associated with non-calcified plaque burden (r = 0.21, p = 0.009; r = 0.48, p<0.001 and r = 0.34, p<0.001, respectively). By multivariate analysis, hsTnT and HMGB1 remained independent predictors of the non-calcified plaque burden (r = 0.48, p<0.01 and r = 0.34, p<0.001, respectively), whereas a non-significant trend was noticed for hs-CRP (r = 0.21, p = 0.07). By combining hsTnT and HMGB1, a high positive predictive value for the presence of non-calcified and remodeled plaque (96% and 77%, respectively) was noted in patients within the upper tertiles for both biomarkers, which surpassed the positive predictive value of each marker separately. In addition to hs-TnT, a well-established cardiovascular risk marker, HMGB1 is independently associated with non-calcified plaque burden in patients with stable CAD, while the predictive value of hs-CRP is lower. Complementary value was observed for hs-TnT and HMGB1 for the prediction of complex coronary plaque.
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影响因子：
5.7
作者：
Korosoglou, Grigorios;Lehrke, Stephanie;Katus, Hugo A.
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