Functional interaction between the RNA exosome and the sirtuin deacetylase Hst3 maintains transcriptional homeostasis.
Functional interaction between the RNA exosome and the sirtuin deacetylase Hst3 maintains transcriptional homeostasis.
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DOI：
10.1101/gad.348923.121
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发表时间：
2022-01-01
影响因子：
10.5
通讯作者：
Peterson CL
中科院分区：
文献类型：
--
作者：
Bryll AR;Peterson CL
在这项研究中，Bryll 等人。发现 RNA 外泌体的失活导致新生 mRNA 转录物的整体减少，并且这种缺陷因组蛋白变体 H2A.Z 沉积的丧失而加剧。他们将 Sirtuin 脱乙酰酶 Hst3 的 mRNA 确定为介导 RNA 降解和转录机器之间通讯的 RNA 外泌体的关键靶标。真核细胞通过平衡 RNA 合成和降解的未知机制维持 mRNA 的最佳水平。我们发现 RNA 外泌体的失活导致新生 mRNA 转录本的整体减少，并且这种缺陷因组蛋白变体 H2A.Z 沉积的丧失而加剧。我们将 Sirtuin 脱乙酰酶 Hst3 的 mRNA 确定为介导 RNA 降解和转录机器之间通讯的 RNA 外泌体的关键靶标。这些发现揭示了 RNA 外泌体和 H2A.Z 如何共同发挥作用来控制脱乙酰酶，确保适当的转录水平以响应 RNA 降解的变化。
In this study, Bryll et al. found that inactivation of the RNA exosome leads to global reduction of nascent mRNA transcripts, and that this defect is accentuated by loss of deposition of histone variant H2A.Z. They identify the mRNA for the sirtuin deacetylase Hst3 as a key target for the RNA exosome that mediates communication between RNA degradation and transcription machineries. Eukaryotic cells maintain an optimal level of mRNAs through unknown mechanisms that balance RNA synthesis and degradation. We found that inactivation of the RNA exosome leads to global reduction of nascent mRNA transcripts, and that this defect is accentuated by loss of deposition of histone variant H2A.Z. We identify the mRNA for the sirtuin deacetylase Hst3 as a key target for the RNA exosome that mediates communication between RNA degradation and transcription machineries. These findings reveal how the RNA exosome and H2A.Z function together to control a deacetylase, ensuring proper levels of transcription in response to changes in RNA degradation.
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