Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma.
Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma.
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DOI：
10.1007/s12250-015-3582-7
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发表时间：
2015-04
影响因子：
5.5
通讯作者：
Ou JH
中科院分区：
文献类型：
--
作者：
Tian Y;Ou JH
B型肝炎病毒（HBV）是肝细胞癌（HCC）的主要病因。其慢性感染可导致慢性肝脏炎症和遗传改变的积累，从而导致肝细胞的致癌转化。HBV还可以通过引起宿主染色体的遗传和表观遗传变化使肝细胞对致癌转化敏感。HBV DNA可以插入宿主染色体，最近的大规模全基因组测序研究显示，HBV DNA整合位点可能在肝细胞癌变的启动中起重要作用。HBV还可以通过改变细胞DNA的甲基化状态、组蛋白的翻译后修饰和microRNA的表达来引起表观遗传变化。这些变化也可能导致最终的肝细胞转化。这些关于HBV诱导的宿主染色体的遗传和表观遗传改变的最新发现为HBV诱导的HCC的新诊断和治疗的发展开辟了新的途径。
Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). Its chronic infection can lead to chronic liver inflammation and the accumulation of genetic alterations to result in the oncogenic transformation of hepatocytes. HBV can also sensitize hepatocytes to oncogenic transformation by causing genetic and epigenetic changes of the host chromosomes. HBV DNA can insert into host chromosomes and recent large-scale whole-genome sequencing studies revealed recurrent HBV DNA integrations sites that may play important roles in the initiation of hepatocellular carcinogenesis. HBV can also cause epigenetic changes by altering the methylation status of cellular DNA, the post-translational modification of histones, and the expression of microRNAs. These changes can also lead to the eventual hepatocellular transformation. These recent findings on the genetic and epigenetic alterations of the host chromosomes induced by HBV opened a new avenue for the development of novel diagnosis and treatments for HBV-induced HCC.
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影响因子：
3.1
作者：
Liang Rongrui;Huang Na;Jiang Shiwen
通讯作者：
Jiang Shiwen
影响因子：
64.8
作者：
CHAKRABORTY, PR;RUIZOPAZO, N;SHAFRITZ, DA
通讯作者：
SHAFRITZ, DA
影响因子：
50.3
作者：
Lau, Chi-Chiu;Sun, Tingting;Wong, Nathalie
通讯作者：
Wong, Nathalie
影响因子：
7
作者：
Jiang, Zhaoshi;Jhunjhunwala, Suchit;Zhang, Zemin
通讯作者：
Zhang, Zemin
影响因子：
4.4
作者：
Li, Weiyang;Zeng, Xi;Zhang, Xiuqing
通讯作者：
Zhang, Xiuqing