Cortical network differences in the sighted versus early blind for recognition of human-produced action sounds.
Cortical network differences in the sighted versus early blind for recognition of human-produced action sounds.
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DOI：
10.1002/hbm.21185
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发表时间：
2011-12
影响因子：
4.8
通讯作者：
Kovach, Amanda L.
中科院分区：
文献类型：
--
作者：
Lewis, James W.;Frum, Chris;Brefczynski-Lewis, Julie A.;Talkington, William J.;Walker, Nathan A.;Rapuano, Kristina M.;Kovach, Amanda L.
视力正常的人和盲人都可以很容易地理解日常真实世界声音背后的含义。在有视力的听众中，我们以前报道过，当听到可识别的动作声时，双侧后上级颞沟（pSTS）和颞中回（pMTG）的沿着区域优先激活。这些区域通常被假设为代表复杂运动处理的主要位点，包括视觉生物运动处理和视听整合。然而，目前还不清楚终身视觉体验是否或在多大程度上可能影响与听觉感知或声源行为记忆相关的功能。使用功能性磁共振成像（fMRI），我们比较了先天性失明与正常听力者在听到各种可识别的人类产生的动作声音（不包括发声）与未识别的反向播放这些声音时激活的大脑区域。在这里，我们表明，公认的人类动作的声音通常诱发活动，在两组沿着大部分的左pSTS/pMTG复合体，虽然与相对更大的活动，在右pSTS/pMTG的盲组。这些结果表明，部分后外侧颞叶皮层包含域特定的枢纽生物和/或复杂的运动处理独立的感觉模态的经验。对比这两组人，视力正常的人优先激活双侧顶叶加内侧和外侧额叶网络，而盲人优先激活左前额叶加双侧前距状核和内侧枕叶区域，包括原本与视觉相关的皮层。这些全球层面的网络差异表明，盲人和视力正常的听众可能会优先使用不同的记忆检索策略时，试图识别动作的声音。
Both sighted and blind individuals can readily interpret meaning behind everyday real-world sounds. In sighted listeners, we previously reported that regions along the bilateral posterior superior temporal sulci (pSTS) and middle temporal gyri (pMTG) are preferentially activated when presented with recognizable action sounds. These regions have generally been hypothesized to represent primary loci for complex motion processing, including visual biological motion processing and audio-visual integration. However, it remained unclear whether, or to what degree, life-long visual experience might impact functions related to hearing perception or memory of sound-source actions. Using functional magnetic resonance imaging (fMRI), we compared brain regions activated in congenitally blind versus sighted listeners in response to hearing a wide range of recognizable human-produced action sounds (excluding vocalizations) versus unrecognized, backward-played versions of those sounds. Here we show that recognized human action sounds commonly evoked activity in both groups along most of the left pSTS/pMTG complex, though with relatively greater activity in the right pSTS/pMTG by the blind group. These results indicate that portions of the postero-lateral temporal cortices contain domain-specific hubs for biological and/or complex motion processing independent of sensory-modality experience. Contrasting the two groups, the sighted listeners preferentially activated bilateral parietal plus medial and lateral frontal networks, while the blind listeners preferentially activated left anterior insula plus bilateral anterior calcarine and medial occipital regions, including what would otherwise have been visual-related cortex. These global-level network differences suggest that blind and sighted listeners may preferentially use different memory retrieval strategies when attempting to recognize action sounds.
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