The Importance of Therapeutically Targeting the Binary Toxin from Clostridioides difficile.
The Importance of Therapeutically Targeting the Binary Toxin from Clostridioides difficile.
复制标题
治疗靶向艰难梭菌二元毒素的重要性。
DOI：
10.3390/ijms22062926
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发表时间：
2021-03-13
影响因子：
5.6
通讯作者：
Weber DJ
中科院分区：
文献类型：
--
作者：
Abeyawardhane DL;Godoy-Ruiz R;Adipietro KA;Varney KM;Rustandi RR;Pozharski E;Weber DJ
需要新颖的治疗方法来治疗与艰难梭菌二元毒素（CDT）相关的病理学，尤其是当艰难梭菌感染（CDI）发生在老年人或患有疾病的住院患者中时，例如癌症可用于阻断与这种医院疾病中大型梭状芽胞杆菌毒素（TCDA和TCDB）相关的毒性具有二进制毒素的CDI。 G-肌动蛋白的ADP-核糖化导致细胞骨架降解和快速细胞死亡。宿主细胞的毒性尚未完全确定，与其他二进制毒素相似。治疗含CDI的含CDI菌株的某些最过度恶毒和致命菌株的策略。
Novel therapeutics are needed to treat pathologies associated with the Clostridioides difficile binary toxin (CDT), particularly when C. difficile infection (CDI) occurs in the elderly or in hospitalized patients having illnesses, in addition to CDI, such as cancer. While therapies are available to block toxicities associated with the large clostridial toxins (TcdA and TcdB) in this nosocomial disease, nothing is available yet to treat toxicities arising from strains of CDI having the binary toxin. Like other binary toxins, the active CDTa catalytic subunit of CDT is delivered into host cells together with an oligomeric assembly of CDTb subunits via host cell receptor-mediated endocytosis. Once CDT arrives in the host cell’s cytoplasm, CDTa catalyzes the ADP-ribosylation of G-actin leading to degradation of the cytoskeleton and rapid cell death. Although a detailed molecular mechanism for CDT entry and host cell toxicity is not yet fully established, structural and functional resemblances to other binary toxins are described. Additionally, unique conformational assemblies of individual CDT components are highlighted herein to refine our mechanistic understanding of this deadly toxin as is needed to develop effective new therapeutic strategies for treating some of the most hypervirulent and lethal strains of CDT-containing strains of CDI.
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影响因子：
158.5
作者：
McDonald, LC;Killgore, GE;Gerding, DN
通讯作者：
Gerding, DN
DOI：
10.1016/s0006-291x(02)02771-7
发表时间：
2003-01-03
影响因子：
3.1
作者：
Gao-Sheridan, S;Zhang, S;Collier, RJ
通讯作者：
Collier, RJ
影响因子：
4
作者：
Eckert, C.;Emirian, A.;Le Monnier, A.;Cathala, L.;De Montclos, H.;Goret, J.;Berger, P.;Petit, A.;De Chevigny, A.;Jean-Pierre, H.;Nebbad, B.;Camiade, S.;Meckenstock, R.;Lalande, V.;Marchandin, H.;Barbut, F.
通讯作者：
Barbut, F.
影响因子：
3.8
作者：
Kobayashi, Keiko;Nagahama, Masahiro;Sakurai, Jun
通讯作者：
Sakurai, Jun
影响因子：
2.7
作者：
Davies AH;McGlashan J;Posner MG;Roberts AK;Shone CC;Acharya KR
通讯作者：
Acharya KR