Depressive Symptoms and Cognitive Decline Among Chinese Rural Elderly Individuals: A Longitudinal Study With 2-Year Follow-Up.
Depressive Symptoms and Cognitive Decline Among Chinese Rural Elderly Individuals: A Longitudinal Study With 2-Year Follow-Up.
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DOI：
10.3389/fpubh.2022.939150
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发表时间：
2022
影响因子：
5.2
通讯作者：
Zhang, Yan
中科院分区：
文献类型：
--
作者：
Zhou, Shuai;Wang, Qiong;Zhang, Jingya;Wang, Qing;Hou, Fangfang;Han, Xiao;Hu, Shilian;Shen, Guodong;Zhang, Yan
抑郁症状和轻度认知障碍（MCI）在中国农村地区非常普遍。本研究旨在探讨中国农村老年人抑郁症状和认知功能下降的变化与MCI发病率之间的纵向关系。对安徽省健康长寿调查（AHLS）的1,477名参与者进行了为期2年的随访研究。抑郁症状通过9项患者健康问卷（PHQ-9）进行评估，认知状态通过简易精神状态检查（MMSE）进行评估。多元线性回归和Logistic回归分析。每增加1个单位的PHQ-9评分，认知功能下降程度显著增加（β = 0.157，95% CI：0.092，0.221，p < 0.001），MCI发生率风险增加（OR = 1.063，95% CI：1.025，1.103，p = 0.001）。经历抑郁症状恶化的参与者的2年MMSE评分下降幅度较大（β = 0.650，95% CI：0.039，1.261，p = 0.037），MCI事件风险升高（OR = 1.573，95% CI：1.113，2.223，p = 0.010）。研究中使用了筛查工具而不是标准诊断程序。此外，由于随访时间较短，长期关联仍需进一步探索。在中国农村居民中，抑郁症状的增加与更多的认知功能下降和更高的MCI发病风险相关。
Depressive symptoms and mild cognitive impairment (MCI) are highly prevalent in rural China. The study aimed to investigate the longitudinal associations between changes in depressive symptoms and cognitive decline and MCI incidence among Chinese rural elderly individuals. A 2-year follow-up study was conducted among 1,477 participants from the Anhui Healthy Longevity Survey (AHLS). Depressive symptoms were assessed by the 9-item Patient Health Questionnaire (PHQ-9), and cognitive status was evaluated by the Mini Mental State Examination (MMSE). Multivariable linear regression and logistic regression were employed. Every 1-unit PHQ-9 score increase was significantly associated with more cognitive decline (β = 0.157, 95% CI: 0.092, 0.221, p < 0.001) and a higher risk of MCI incidence (OR = 1.063, 95% CI: 1.025, 1.103, p = 0.001). The participants who experienced worsening of depression symptoms had a larger decline in the 2-year MMSE score (β = 0.650, 95% CI: 0.039, 1.261, p = 0.037) and elevated risks of incident MCI (OR = 1.573, 95% CI: 1.113, 2.223, p = 0.010). Screening tools rather than standard diagnostic procedures were used in the study. Moreover, the long-term associations still need further exploration since the follow-up time was short. Increased depressive symptoms were associated with more cognitive decline and higher risks of incident MCI among Chinese rural residents.
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影响因子：
2.9
作者：
Jansen MG;Geerligs L;Claassen JAHR;Overdorp EJ;Brazil IA;Kessels RPC;Oosterman JM
通讯作者：
Oosterman JM
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作者：
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影响因子：
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作者：
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通讯作者：
Fiest, Kirsten M.
影响因子：
6.4
作者：
Fangfang，H.;Xiao，H.;Yan，Z.
通讯作者：
Yan，Z.