Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation.
Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation.
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DOI：
10.1016/j.drugalcdep.2012.04.021
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发表时间：
2012-11-01
影响因子：
4.2
通讯作者：
Rawls SM
中科院分区：
文献类型：
--
作者：
Lisek R;Xu W;Yuvasheva E;Chiu YT;Reitz AB;Liu-Chen LY;Rawls SM
在美国，滥用一种名为甲氧麻黄酮（4-甲基甲卡西酮）的危险街头毒品已经司空见惯。据推测，吗啡酮具有滥用倾向，与精神兴奋剂具有相同的药理学特性，并显示出与死亡和非致命性过量有关的毒性。4-甲基甲卡西酮的药理学知识主要来自对药物滥用者的调查和急诊室访问，而不是实验研究。本研究采用运动活动和条件性位置偏爱（CPP）实验研究了甲氧麻黄酮的行为效应。急性甲氧麻黄酮（3，5，10，30毫克/公斤，ip）管理增加大鼠的走动活动。多巴胺D1受体拮抗剂（SCH 23390）（0.5、1、2 mg/kg，ip）预处理可抑制吗啡酮（5 mg/kg，ip）诱导的Amp，多巴胺D2受体拮抗剂（舒必利）（2 mg/kg，ip）预处理可增强吗啡酮（5 mg/kg，ip）诱导的Amp。给大鼠腹腔注射低剂量甲氧麻黄酮（0.5 mg/kg，ip）5 d，戒断10 d后再用甲氧麻黄酮（0.5 mg/kg，ip）激发，表现出步行活动的增敏作用。在CPP实验中，甲氧麻黄酮（30 mg/kg，ip）条件化引起大鼠和小鼠的偏好转变。由甲氧麻黄酮产生的CPP和多巴胺敏感性运动激活提示滥用倾向，并表明甲氧麻黄酮和已确定的滥用药物的神经药理学特征之间的共性。
Abuse of a dangerous street drug called mephedrone (4-methylmethcathinone) has become commonplace in the United States. Mephedrone is hypothesized to possess abuse liability, share pharmacological properties with psychostimulants, and display toxicity that has been linked to fatalities and non-fatal overdoses. Knowledge about the pharmacology of mephedrone has been obtained primarily from surveys of drug abusers and emergency room visits rather than experimental studies. The present study used motor activity and conditioned place preference (CPP) assays to investigate behavioral effects of mephedrone. Acute mephedrone (3, 5, 10, 30 mg/kg, ip) administration increased ambulatory activity in rats. Mephedrone (5 mg/kg, ip)-induced ambulation was inhibited by pretreatment with a dopamine D1 receptor antagonist (SCH 23390) (0.5, 1, 2 mg/kg, ip) and enhanced by pretreatment with a dopamine D2 receptor antagonist (sulpiride) (2 mg/kg, ip). Rats injected for 5 days with low dose mephedrone (0.5 mg/kg, ip) and then challenged with mephedrone (0.5 mg/kg, ip) following 10 days of abstinence displayed sensitization of ambulatory activity. In CPP experiments, mephedrone (30 mg/kg, ip) conditioning elicited a preference shift in both rats and mice. The CPP and dopamine-sensitive motor activation produced by mephedrone is suggestive of abuse liability and indicates commonalities between the neuropharmacological profiles of mephedrone and established drugs of abuse.
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影响因子：
5.3
作者：
Benoit-Marand, M;Borrelli, E;Gonon, F
通讯作者：
Gonon, F
影响因子：
4.2
作者：
Carhart-Harris, R. L.;King, L. A.;Nutt, D. J.
通讯作者：
Nutt, D. J.
影响因子：
4.7
作者：
Angoa-Pérez M;Kane MJ;Francescutti DM;Sykes KE;Shah MM;Mohammed AM;Thomas DM;Kuhn DM
通讯作者：
Kuhn DM
影响因子：
7.3
作者：
Kehr, J.;Ichinose, F.;Yoshitake, T.
通讯作者：
Yoshitake, T.
影响因子：
5
作者：
Jaworski, JN;Gonzales, RA;Randall, PK
通讯作者：
Randall, PK