Pediatric Cancers among Alaska Native People.
Pediatric Cancers among Alaska Native People.
复制标题
DOI：
10.1016/j.jpeds.2020.07.036
复制
发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Hirschfeld M
中科院分区：
文献类型：
--
作者：
Nash SH;Zimpelman G;Schulz L;Hirschfeld M
评估阿拉斯加原住民 (AN) 人群中儿童癌症的描述性流行病学。我们使用了阿拉斯加原住民肿瘤登记处的数据，这是一个基于人口的登记处，记录了 1969 年至今阿拉斯加原住民的癌症信息。具体来说，我们检查了 0-19 岁个体中诊断出的所有癌症病例。根据国际儿童癌症分类，第三版（ICCC-3）对病例进行分类。我们通过比较 1969-1996 年和 1997-2016 年的时间段，按 ICCC-3 癌症部位估算了病例的发病率和分布。我们评估了 12 个月和 5 年的病因特异性生存率，并检查了一段时间内的差异，并根据年龄、性别和 ICCC-3 站点进行了调整。 1969-1996 年 (n = 134) 和 1997-2016 年 (n = 186) 期间，阿拉斯加原住民的儿科癌症发病率从 139.8/1,000,000（95% 置信区间 (CI)：116.99, 165.7）增加到197.54/1,000,000（95% CI：170.1，228.1）。 ICCC-3 位点的分布随时间段的不同而不同 (P<0.0001)。最后，癌症存活率很高。所有ICCC-3站点的12个月生存概率合计为0.88（95% CI：0.84，0.92），五年生存概率为0.76（0.70，0.81）（1969-2016）。在调整年龄、性别和 ICCC-3 站点后，我们将 1997-2016 年诊断的 AN 儿童癌症病例与 1969-1996 年诊断的儿童癌症病例进行比较，观察到死亡风险降低了 57%。这些信息对于我们了解美国原住民中的儿科癌症非常有价值，也将为为该人群提供护理的临床医生提供信息。
To evaluate the descriptive epidemiology of pediatric cancers among Alaska Native (AN) people. We used data from the Alaska Native Tumor Registry, a population-based registry capturing cancer information among Alaska Native people 1969-present. Specifically, we examined all cases of cancer diagnosed among individuals ages 0-19 years. Cases were classified according to the International Classification of Childhood Cancers, 3rd edition (ICCC-3). We estimated incidence and distribution of cases by ICCC-3 cancer site, comparing between the time-periods 1969-1996, and 1997-2016. We assessed twelve month and five-year cause-specific survival, and examined differences over time-period, adjusted for age, sex, and ICCC-3 site. Incidence rates of pediatric cancers increased between 1969-1996 (n = 134), and 1997-2016 (n = 186) among Alaska Native people, from 139.8/1,000,000 (95% Confidence Interval (CI): 116.99, 165.7) to 197.54/1,000,000 (95% CI: 170.1, 228.1). Distribution of ICCC-3 sites differed between time-periods (P<0.0001). Finally, cancer survival was high; 12-month survival probability from all ICCC-3 sites combined was 0.88 (95% CI: 0.84, 0.92) and five-year survival probability was 0.76 (0.70, 0.81) (1969-2016). After adjusting for age, sex, and ICCC-3 site, we observed a 57% reduction in risk of death when comparing AN pediatric cancer cases diagnosed in 1997-2016 to those diagnosed in 1969-1996. This information will be of value for our understanding of pediatric cancers among Indigenous peoples of the U.S., and will also be informative for clinicians providing care to this population.
登录
查看更多内容
影响因子：
8
作者：
American Academy of Pediatrics Section on Hematology/Oncology Children's Oncology Group
通讯作者：
American Academy of Pediatrics Section on Hematology/Oncology Children's Oncology Group
影响因子：
6.2
作者：
Aziz, Noreen M.;Oeffinger, Kevin C.;Turoff, Alicia J.
通讯作者：
Turoff, Alicia J.
影响因子：
3.5
作者：
Etz, Kathleen E.;Arroyo, Judith A.
通讯作者：
Arroyo, Judith A.
影响因子：
2.5
作者：
Nostedt, Michelle C.;McKay, Andrew M.;Park, Jason
通讯作者：
Park, Jason
影响因子：
4.7
作者：
Shalowitz, David I.;Nivasch, Esther;Schapira, Marilyn M.
通讯作者：
Schapira, Marilyn M.