Enhanced Triggering of Local Anesthetic Particles by Photosensitization and Photothermal Effect Using a Common Wavelength.
Enhanced Triggering of Local Anesthetic Particles by Photosensitization and Photothermal Effect Using a Common Wavelength.
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DOI：
10.1021/acs.nanolett.7b04176
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发表时间：
2017-11-08
期刊：
影响因子：
10.8
通讯作者：
Kohane DS
中科院分区：
文献类型：
--
作者：
Rwei AY;Wang BY;Ji T;Zhan C;Kohane DS
按需疼痛缓解系统将是非常有用的补充医疗设备的疼痛管理。近红外触发的药物递送系统已经证明了提供这种护理的潜力。然而，在使这样的系统尽可能刺激敏感以增强组织穿透深度、触发的可重复性和安全性方面仍然存在挑战。在这里，我们开发了含有局部麻醉剂河豚毒素的脂质体，还含有光敏剂和在相同的近红外波长下可激发的金纳米棒。当与具有单一光响应组分的脂质体相比时，该组合增强了体外系统的光敏性和重复性。在体内，低辐照度和短照射时间即可诱导按需局部麻醉，同时含有光敏剂和金纳米棒的脂质体比仅含有一种光敏成分的脂质体更有效。组织反应为良性。
On-demand pain relief systems would be very helpful additions to the armamentarium of pain management. Near-infrared triggered drug delivery systems have demonstrated the potential to provide such care. However, challenges remain in making such systems as stimulus-sensitive as possible, to enhance depth of tissue penetration, repeatability of triggering, and safety. Here we developed liposomes containing the local anesthetic tetrodotoxin and also containing a photosensitizer and gold nanorods that were excitable at the same near-infrared wavelengths. The combination enhanced the photosensitivity and repeatability of the system in vitro when compared with liposomes with a single photoresponsive component. In vivo, on-demand local anesthesia could be induced with a low irradiance and short irradiation duration, and liposomes containing both photosensitizer and gold nanorods were more effective than those containing just one photoresponsive component. Tissue reaction was benign.
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