The impact of within-vector parasite development on the extrinsic incubation period.
The impact of within-vector parasite development on the extrinsic incubation period.
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DOI：
10.1098/rsos.192173
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发表时间：
2020-10
影响因子：
3.5
通讯作者：
Prosper OF
中科院分区：
文献类型：
--
作者：
Childs LM;Prosper OF
蚊子传播的疾病，特别是疟疾，在全世界造成重大负担，每年导致近50万人死亡。疟疾寄生虫需要脊椎动物宿主（如人类）和媒介宿主（按蚊）才能完成其整个生命周期。在这里，我们专注于载体内的寄生虫动力学检查子孢子在唾液腺中的首次出现，这表明蚊子的第一次传染性。蚊子体内病原体发展到可传播性的这段时间，称为外源性潜伏期，仍然知之甚少。我们开发了室内蚊子寄生虫的动力学模型，与卵囊和子孢子计数的实验数据拟合。我们发现，只有一小部分的卵囊爆裂释放子孢子和爆裂必须通过一个时间依赖性的功能或伽马分布的一组隔间延迟。我们使用贝叶斯推断来估计参数的分布，并确定爆发率是一个关键的流行病学参数。更好地了解影响外在潜伏期的因素将有助于制定减缓或阻止疟疾传播的干预措施。
Mosquito-borne diseases, in particular malaria, have a significant burden worldwide leading to nearly half a million deaths each year. The malaria parasite requires a vertebrate host, such as a human, and a vector host, the Anopheles mosquito, to complete its full life cycle. Here, we focus on the parasite dynamics within the vector to examine the first appearance of sporozoites in the salivary glands, which indicates a first time of infectiousness of mosquitoes. The timing of this period of pathogen development in the mosquito until transmissibility, known as the extrinsic incubation period, remains poorly understood. We develop compartmental models of within-mosquito parasite dynamics fitted with experimental data on oocyst and sporozoite counts. We find that only a fraction of oocysts burst to release sporozoites and bursting must be delayed either via a time-dependent function or a gamma-distributed set of compartments. We use Bayesian inference to estimate distributions of parameters and determine that bursting rate is a key epidemiological parameter. A better understanding of the factors impacting the extrinsic incubation period will aid in the development of interventions to slow or stop the spread of malaria.
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影响因子：
2
作者：
Boersch-Supan, Philipp H.;Johnson, Leah R.
通讯作者：
Johnson, Leah R.
DOI：
10.1016/j.trstmh.2009.03.009
发表时间：
2009-12-01
影响因子：
2.2
作者：
Dawes, Emma J.;Zhuang, Shijie;Basanez, Maria-Gloria
通讯作者：
Basanez, Maria-Gloria
DOI：
10.4269/ajtmh.12-0007
发表时间：
2013-05
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Eckhoff P
通讯作者：
Eckhoff P
影响因子：
3.7
作者：
Childs, Lauren M.;Prosper, Olivia F.
通讯作者：
Prosper, Olivia F.
影响因子：
2.4
作者：
Hetzel, C;Anderson, RM
通讯作者：
Anderson, RM