Mathematical models of within-host and transmission dynamics to determine effects of malaria interventions in a variety of transmission settings.
Mathematical models of within-host and transmission dynamics to determine effects of malaria interventions in a variety of transmission settings.
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DOI：
10.4269/ajtmh.12-0007
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Eckhoff P
中科院分区：
文献类型：
--
作者：
Eckhoff P
按蚊种群动态和疟疾传播模型与宿主内动态微解算器相结合，研究基线传播、季节性影响和干预措施的影响。 Garki 项目是通过模拟干预前基线和部署的干预措施的不同组合来重新创建的。进行了修改，延长了项目持续时间，延长了旱季喷洒时间，并使用阻断传播的疫苗，在某些情况下实现了局部消除。在传播强度和潜在季节性各不相同的传播环境中模拟了各种干预措施。在现有病媒控制工作中添加疫苗，可以提高消除基线传播和不良病媒行为的能力。如果冈比亚按蚊物种复合体中的一个物种对于给定的复合平均行为不成比例地在户外进食，则病媒控制影响小于单个物种。非零旱季传播限制了寄生虫动态的季节性波动和雨季干预措施的影响。
A model for Anopheles population dynamics and malaria transmission is combined with a within-host dynamics microsolver to study baseline transmission, the effects of seasonality, and the impact of interventions. The Garki Project is recreated in simulation of the pre-intervention baseline and the different combinations of interventions deployed. Modifications are introduced, and longer project duration, extension of dry-season spraying, and transmission-blocking vaccines together achieve local elimination in some conditions. A variety of interventions are simulated in transmission settings that vary in transmission intensity and underlying seasonality. Adding vaccines to existing vector control efforts extends the ability to achieve elimination to higher baseline transmission and less favorable vector behavior. If one species of the Anopheles gambiae species complex feeds disproportionately outdoors for a given complex average behavior, vector control impacts are less than for a single species. Non-zero dry-season transmission limits seasonal oscillation in parasite dynamics and impact of wet-season interventions.
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影响因子：
3.3
作者：
Fillinger, U;Sonye, G;Becker, N
通讯作者：
Becker, N
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
3
作者：
Eckhoff PA
通讯作者：
Eckhoff PA
影响因子：
3
作者：
Eckhoff PA
通讯作者：
Eckhoff PA
影响因子：
3
作者：
Ferguson HM;Maire N;Takken W;Lyimo IN;Briët O;Lindsay SW;Smith TA
通讯作者：
Smith TA