Pregnancy-associated progenitor cells: an under-recognized potential source of stem cells in maternal lung.
Pregnancy-associated progenitor cells: an under-recognized potential source of stem cells in maternal lung.
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DOI：
10.1016/j.placenta.2011.04.007
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发表时间：
2011-10
期刊：
影响因子：
3.8
通讯作者：
Bianchi, D. W.
中科院分区：
文献类型：
--
作者：
Pritchard, S.;Hoffman, A. M.;Johnson, K. L.;Bianchi, D. W.
关键词：
急性和慢性肺部疾病的治疗需要新的疗法，其中许多是无法治愈的。外源性干细胞的使用在动物模型和临床试验中都显示出了希望。然而，迄今为止，干细胞文献对自然获得的妊娠相关祖细胞（PAPC）认识不足。这些细胞存在于女性组织的损伤或疾病部位。它们在分娩后的数十年内持续存在于母体血液和器官中，其中最大数量存在于母体肺部。它们的存在可能是某些肺部疾病的患病率和预后存在性别差异的一种解释。虽然这些细胞的临床意义尚不清楚，但文献表明一些PAPC是干细胞或具有干细胞样特性。从经产妇女的血液或器官中收获的PAPC可能被用作具有再生特性的细胞的替代来源，用于妇女自己或她的孩子。由于PAPC优先运输到母体肺，因此它们可能在肺部疾病的恢复或保护中发挥重要作用。在这篇综述文章中，我们讨论了正在进行的研究，调查成人和胎盘来源的干细胞治疗肺部疾病的管理，以及PAPC如何也可能发挥重要的未来治疗作用。
Novel therapies are needed for the treatment of acute and chronic lung diseases, many of which are incurable. The use of exogenous stem cells has shown promise in both animal models and clinical trials. However, to date, the stem cell literature has under-recognized naturally acquired pregnancy-associated progenitor cells (PAPCs). These cells are found at sites of injury or disease in female tissues. They persist for decades after parturition in maternal blood and organs, with the largest number being found in the maternal lungs. Their presence there may be one explanation for the sex differences observed in the prevalence and prognosis of some lung diseases. Although the clinical significance of these cells is as yet unknown, the literature suggests that some of the PAPCs are stem cells or have stem cell-like properties. PAPCs harvested from the blood or organs of parous women could potentially be used as an alternate source of cells with regenerative properties for the woman herself or her children. Because PAPCs preferentially traffic to the maternal lung they may play a significant role in recovery or protection from lung disease. In this review article, we discuss ongoing research investigating the administration of both adult and placenta-derived stem cells to treat lung disease, and how PAPCs may also play an important future therapeutic role.
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DOI：
10.1165/rcmb.2002-0056rc
发表时间：
2002-12-01
影响因子：
6.4
作者：
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