Endocannabinoid modulation of dopamine neurotransmission.
Endocannabinoid modulation of dopamine neurotransmission.
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DOI：
10.1016/j.neuropharm.2017.04.033
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发表时间：
2017-09-15
影响因子：
4.7
通讯作者：
Lovinger DM
中科院分区：
文献类型：
--
作者：
Covey DP;Mateo Y;Sulzer D;Cheer JF;Lovinger DM
多巴胺(DA)是哺乳动物大脑中一种主要的儿茶酚胺神经递质，它控制着涉及目标定向行为的认知、情感和运动方面的神经回路。因此，DA神经传递的紊乱在几种神经精神障碍中起着核心作用。考虑到DA在许多行为中的突出作用，有些令人惊讶的是，DA是由起源于中脑的相对较少的密集排列的神经元释放的。多巴胺能中脑支配许多脑区，细胞外DA释放和受体结合促进突触后神经元功能的短期和长期变化。纹状体前脑核团接受DA投射的比例最大，是DA影响行为的主要枢纽。许多兴奋性、抑制性和调节性输入通过控制DA细胞体的放电模式、终末释放和对纹状体突触后部位的影响来协调DA神经传递。内源性大麻素(ECB)系统作为传入输入的重要过滤器，在中脑和终末区局部作用，影响传入信息如何传递到DA神经元和输出靶点。在这篇综述中，我们旨在强调关于ECB信号如何通过改变中脑和纹状体部位的突触强度来控制DA神经元功能的现有知识，并就这一主题提出悬而未决的问题。
Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that controls neural circuits involved in the cognitive, emotional, and motor aspects of goal-directed behavior. Accordingly, perturbations in DA neurotransmission play a central role in several neuropsychiatric disorders. Somewhat surprisingly given its prominent role in numerous behaviors, DA is released by a relatively small number of densely packed neurons originating in the midbrain. The dopaminergic midbrain innervates numerous brain regions where extracellular DA release and receptor binding promote short- and long-term changes in postsynaptic neuron function. Striatal forebrain nuclei receive the greatest proportion of DA projections and are a predominant hub at which DA influences behavior. A number of excitatory, inhibitory, and modulatory inputs orchestrate DA neurotransmission by controlling DA cell body firing patterns, terminal release, and effects on postsynaptic sites in the striatum. The endocannabinoid (eCB) system serves as an important filter of afferent input that acts locally at midbrain and terminal regions to shape how incoming information is conveyed onto DA neurons and to output targets. In this review, we aim to highlight existing knowledge regarding how eCB signaling controls DA neuron function through modifications in synaptic strength at midbrain and striatal sites, and to raise outstanding questions on this topic.
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DOI：
10.1073/pnas.1834314100
发表时间：
2003-09-30
影响因子：
11.1
作者：
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