Bisphosphonate uptake in areas of tooth extraction or periapical disease.
Bisphosphonate uptake in areas of tooth extraction or periapical disease.
复制标题
DOI：
10.1016/j.joms.2014.07.004
复制
发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Tetradis S
中科院分区：
文献类型：
--
作者：
Cheong S;Sun S;Kang B;Bezouglaia O;Elashoff D;McKenna CE;Aghaloo TL;Tetradis S
双膦酸盐（BPs）广泛用于骨质疏松症和骨恶性肿瘤等骨疾病的治疗。然而，颌骨骨坏死（ONJ）是BP治疗的严重并发症。ONJ病变主要发生在被认为不可修复的牙齿拔除后或患有活动性牙周病或根尖周病的牙齿周围。由于牙槽愈合或牙科疾病显示较高的骨转换，作者假设在这些区域优先观察到高血压蓄积。作者测试了荧光素标记的唑来膦酸（5-FAM-ZOL）在小鼠拔牙或实验性根尖周病部位的摄取。拔除上颌磨牙或钻取下颌磨牙牙冠，诱导牙髓暴露。在干预后的不同时间给动物注射200 μg/kg 5-FAM-ZOL，并在健康部位与干预部位测量荧光。将黄绿素注射液用作对照。通过t检验分析数据，并构建混合效应线性模型，因为动物随着时间的推移在2个地点进行了重复测量。与相同动物的健康对侧部位相比，在拔牙窝区域和根尖周疾病牙齿周围的牙槽嵴中检测到5-FAM-ZOL的时间依赖性摄取，具有统计学显著性（P ≤ .001至.002）。对于这两种条件，摄取在实验干预后3天达到最大值，此后下降。这些数据表明，骨转换增加的部位，如拔牙部位或根尖周炎症区域，暴露于比剩余牙槽嵴更高的BP剂量，至少可以部分解释这些区域对ONJ的敏感性。
Bisphosphonates (BPs) are widely used for the management of bone diseases such as osteoporosis and bone malignancy. However, osteonecrosis of the jaws (ONJ) is a serious complication of BP treatment. ONJ lesions mainly occur after extraction of teeth deemed unrestorable or around teeth with active periodontal or periapical disease. Because socket healing or dental disease shows higher bone turnover, the authors hypothesized that preferentially high BP accumulation would be observed in these areas. The authors tested the uptake of fluorescein-labeled zoledronic acid (5-FAM-ZOL) in sites of tooth extraction or experimental periapical disease in mice. Maxillary molars were extracted or the crowns of mandibular molars were drilled to induce pulp exposure. Animals were injected with 5-FAM-ZOL 200 μg/kg at various times after intervention and fluorescence was measured at healthy versus intervention sites. Fluorescein injections were used as controls. Data were analyzed by t test and mixed effects linear models were constructed because the animals had repeated measurements over time and at the 2 sites. A statistically significant (P ≤ .001 to .002) time-dependent uptake of 5-FAM-ZOL was detected in the areas of extraction socket and in the alveolar ridge around teeth with periapical disease compared with the healthy contralateral sites of the same animals. For the 2 conditions, the uptake reached a maximum 3 days after experimental intervention and decreased thereafter. These data suggest that sites with increased bone turnover, such as extraction sites or areas of periapical inflammation, are exposed to higher BP doses than the remaining alveolar ridge and could explain, at least in part, the susceptibility of such areas to ONJ.
登录
查看更多内容
影响因子：
6.2
作者：
Mavropoulos, Anestis;Rizzoli, Rene;Ammann, Patrick
通讯作者：
Ammann, Patrick
影响因子：
6.2
作者：
Roelofs, Anke J.;Stewart, Charlotte A.;Coxon, Fraser P.
通讯作者：
Coxon, Fraser P.
影响因子：
4.3
作者：
Chaichanasakul T;Kang B;Bezouglaia O;Aghaloo TL;Tetradis S
通讯作者：
Tetradis S
DOI：
10.1111/j.1749-6632.2010.05835.x
发表时间：
2011-01-01
期刊：
BISPHOSPHONATES AND OSTEONECROSIS OF THE JAW
影响因子：
--
作者：
Landesberg, Regina;Woo, Victoria;Raghavan, Srikala
通讯作者：
Raghavan, Srikala
DOI：
10.1016/j.oooo.2013.05.005
发表时间：
2013-09-01
影响因子：
2.9
作者：
Pichardo, Sarina E. C.;van Merkesteyn, J. P. Richard
通讯作者：
van Merkesteyn, J. P. Richard