Intranasal COVID-19 vaccines: From bench to bed.
Intranasal COVID-19 vaccines: From bench to bed.
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DOI：
10.1016/j.ebiom.2022.103841
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发表时间：
2022-03
期刊：
影响因子：
11.1
通讯作者：
Wei X
中科院分区：
文献类型：
--
作者：
Alu A;Chen L;Lei H;Wei Y;Tian X;Wei X
目前获得许可的COVID-19疫苗均设计用于肌内（IM）免疫。然而，今天的疫苗接种未能预防病毒通过上呼吸道感染，这部分是由于缺乏粘膜免疫激活。尽管出现了严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）变体，但仍需要下一代COVID-19疫苗，并且鼻内（IN）接种方法已被证明在诱导粘膜和全身免疫应答方面有效。目前，尽管尚未获得许可，但针对SARS-CoV-2的各种IN疫苗正在进行深入研究，有12种候选疫苗在不同阶段进入临床试验。本文就新型冠状病毒疫苗、重组亚单位疫苗和减毒活疫苗的研究现状进行综述。正在进行的IN疫苗的临床试验突出显示。此外，还总结了粘膜免疫的潜在机制以及潜在的粘膜佐剂和鼻内给药装置。
Currently licensed COVID-19 vaccines are all designed for intramuscular (IM) immunization. However, vaccination today failed to prevent the virus infection through the upper respiratory tract, which is partially due to the absence of mucosal immunity activation. Despite the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, the next generation of COVID-19 vaccine is in demand and intranasal (IN) vaccination method has been demonstrated to be potent in inducing both mucosal and systemic immune responses. Presently, although not licensed, various IN vaccines against SARS-CoV-2 are under intensive investigation, with 12 candidates reaching clinical trials at different phases. In this review, we give a detailed description about current status of IN COVID-19 vaccines, including virus-vectored vaccines, recombinant subunit vaccines and live attenuated vaccines. The ongoing clinical trials for IN vaccines are highlighted. Additionally, the underlying mechanisms of mucosal immunity and potential mucosal adjuvants and nasal delivery devices are also summarized.
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DOI：
10.1016/j.xcrm.2021.100230
发表时间：
2021-04-20
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Hassan AO;Feldmann F;Zhao H;Curiel DT;Okumura A;Tang-Huau TL;Case JB;Meade-White K;Callison J;Chen RE;Lovaglio J;Hanley PW;Scott DP;Fremont DH;Feldmann H;Diamond MS
通讯作者：
Diamond MS
影响因子：
56.9
作者：
Hsieh, Ching-Lin;Goldsmith, Jory A.;McLellan, Jason S.
通讯作者：
McLellan, Jason S.
影响因子：
4.6
作者：
Bal, Suzanne M.;Slutter, Bram;Jiskoot, Wim
通讯作者：
Jiskoot, Wim
影响因子：
7.4
作者：
Chavda VP;Vora LK;Pandya AK;Patravale VB
通讯作者：
Patravale VB
影响因子：
7.8
作者：
Chandrasekar SS;Phanse Y;Hildebrand RE;Hanafy M;Wu CW;Hansen CH;Osorio JE;Suresh M;Talaat AM
通讯作者：
Talaat AM