Is carotid intima-media thickness as predictive as other noninvasive techniques for the detection of coronary artery disease?
Is carotid intima-media thickness as predictive as other noninvasive techniques for the detection of coronary artery disease?
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颈动脉内膜中层厚度是否可以像其他检测冠状动脉疾病的无创技术一样具有预测性？
DOI：
10.1161/atvbaha.113.302075
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Wasserman,BruceA
中科院分区：
文献类型：
--
作者：
Zhang,Yiyi;Guallar,Eliseo;Qiao,Ye;Wasserman,BruceA
B超测量颈动脉内膜中层厚度（CIMT）是评估动脉粥样硬化和心血管风险最广泛使用的无创成像方法。CIMT一直与冠状动脉疾病和卒中相关;然而，最近的荟萃分析和系统评价表明，其临床用途可能有限，因为将CIMT添加到传统风险因素中并没有改善普通人群中心血管事件的风险预测。与超声测量CIMT相比，通过MRI表征颈动脉壁可能具有更大的临床实用性。与CIMT不同，MRI测量的壁厚包括外膜，并且可能对作为早期斑块发展标志的血管增生导致的外膜增厚敏感。MRI还能够对颈动脉壁的整个圆周进行成像，包括颈动脉球的外壁，其中斑块在其最早阶段形成，并识别与斑块脆弱性和心血管风险密切相关的斑块成分，如脂质核心，纤维帽和斑块内出血。需要进一步的研究来评估MRI测量壁和斑块特征在传统风险因素之外的风险预测中的附加预后价值。
Carotid intima-media thickness (CIMT) measured by B-mode ultrasound is the most widely used noninvasive imaging method to assess atherosclerosis and cardiovascular risk. CIMT has been consistently associated with coronary artery disease and stroke; however, recent meta-analyses and systematic reviews suggest that its clinical usefulness may be limited because the addition of CIMT to traditional risk factors has not improved the risk prediction of cardiovascular events in the general population. Characterizing the carotid wall by MRI may have greater clinical utility compared with CIMT measurements by ultrasound. Unlike CIMT, MRI measurements of wall thickness include the adventitia and may be sensitive to adventitial thickening that results from vasa vasorum proliferation as a sign of early plaque development. MRI also has the ability to image the entire circumference of the carotid wall, including the outer wall of the carotid bulb where plaque forms in its earliest stage, and identify plaque components such as the lipid core, fibrous cap, and intraplaque hemorrhage that are closely related to plaque vulnerability and cardiovascular risk. Additional research is needed to assess the added prognostic value of MRI measurements of wall and plaque features in risk prediction beyond traditional risk factors.
甲状旁腺激素：化学、生物合成和作用方式。
影响因子：
--
作者：
J. Potts;H. Kronenberg;M. Rosenblatt
通讯作者：
M. Rosenblatt
维生素D3、1,25-二羟基维生素D3和24,25-二羟基维生素D3对器官培养中甲状旁腺激素分泌、3,5-单磷酸腺苷释放和甲状旁腺超微结构的影响。
影响因子：
4.8
作者：
M. Dietel;G. Dorn;R. Montz;E. Altenähr
通讯作者：
E. Altenähr