A review on experimental and clinical genetic associations studies on fear conditioning, extinction and cognitive-behavioral treatment.
A review on experimental and clinical genetic associations studies on fear conditioning, extinction and cognitive-behavioral treatment.
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DOI：
10.1038/tp.2011.36
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发表时间：
2011-09-20
影响因子：
6.8
通讯作者：
Kalisch R
中科院分区：
文献类型：
--
作者：
Lonsdorf TB;Kalisch R
恐惧条件反射和恐惧消退是联想学习的基本形式，具有相当大的临床意义，并与焦虑症的发病机制有关。在获得和消除条件性恐惧反应的能力方面存在相当大的个体间差异，并且遗传变异的研究最近已成为研究的焦点。在这篇综述中，我们概述了现有的人类恐惧条件反射和灭绝的健康个体和认知行为治疗（CBT）和暴露，以及创伤后病理发展的相关研究的遗传关联研究。5-羟色胺转运蛋白（5 HTT）和儿茶酚-O-甲基转移酶（COMT）基因的变异一直与临床前和临床研究中的效应相关。有趣的新发现，但需要进一步复制，已报告的遗传变异的多巴胺转运蛋白（DAT 1）和垂体腺苷酸环化酶1受体（ADCYAP 1 R1）基因，而目前的图片是不一致的变化，脑源性神经营养因子（BDNF）基因。最后，我们讨论的结果和他们的局限性，以及未来的方向，我们希望将有助于该领域进一步发展。
Fear conditioning and extinction represent basic forms of associative learning with considerable clinical relevance and have been implicated in the pathogenesis of anxiety disorders. There is considerable inter-individual variation in the ability to acquire and extinguish conditioned fear reactions and the study of genetic variants has recently become a focus of research. In this review, we give an overview of the existing genetic association studies on human fear conditioning and extinction in healthy individuals and of related studies on cognitive-behavioral treatment (CBT) and exposure, as well as pathology development after trauma. Variation in the serotonin transporter (5HTT) and the catechol-o-methyltransferase (COMT) genes has consistently been associated with effects in pre-clinical and clinical studies. Interesting new findings, which however require further replication, have been reported for genetic variation in the dopamine transporter (DAT1) and the pituitary adenylate cyclase 1 receptor (ADCYAP1R1) genes, whereas the current picture is inconsistent for variation in the brain-derived neurotrophic factor (BDNF) gene. We end with a discussion of the findings and their limitations, as well as future directions that we hope will aid the field to develop further.
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.012464099
发表时间：
2002-01-08
影响因子：
11.1
作者：
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通讯作者：
Moyzis, RK