Prevalence and identification of anxiety disorders in pregnancy: the diagnostic accuracy of the two-item Generalised Anxiety Disorder scale (GAD-2).
Prevalence and identification of anxiety disorders in pregnancy: the diagnostic accuracy of the two-item Generalised Anxiety Disorder scale (GAD-2).
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DOI：
10.1136/bmjopen-2018-023766
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发表时间：
2018-09-05
期刊：
影响因子：
2.9
通讯作者：
Howard LM
中科院分区：
文献类型：
--
作者：
Nath S;Ryan EG;Trevillion K;Bick D;Demilew J;Milgrom J;Pickles A;Howard LM
估计妊娠期焦虑障碍的人群患病率，并研究两项广泛性焦虑障碍量表（GAD-2）对a）GAD和B）任何焦虑障碍的诊断准确性。横断面调查采用分层抽样设计。在分析中使用了抽样权重，以调整分层抽样引入的偏倚。市内妇产科服务，南伦敦。545名孕妇进行了采访后，他们的第一次产前预约，528提供了答案的性别与发展-2的问题。由精神疾病诊断和统计手册结构化临床访谈（第4版）（SCID）生成的诊断。焦虑障碍的人群患病率为17%（95% CI 12%至21%）：GAD为5%（95% CI 3%至6%），社交恐怖症为4%（95% CI 2%至6%），特定恐怖症为8%（95% CI 5%至11%），强迫症为2%（95% CI 1%至4%）。创伤后应激障碍（PTSD）的患病率尚不清楚，由于较高水平的不愿意回答PTSD访谈问题，但敏感性分析表明，人口患病率可能高达4%（95%CI 2%至6%）。GAD-2对GAD的加权敏感性（临界值≥3）为69%，特异性为91%，阳性预测值为26%，阴性预测值为98%，似然比为7.35。对于任何焦虑障碍，加权敏感性为26%，特异性为91%，阳性预测值为36%，阴性预测值为87%，似然比为2.92。焦虑症是常见的，但GAD-2产生许多假阳性，因此可能对产科服务没有帮助。
To estimate the population prevalence of anxiety disorders during pregnancy and investigate the diagnostic accuracy of the two-item Generalised Anxiety Disorder scale (GAD-2) for a) GAD and b) any anxiety disorder. Cross-sectional survey using a stratified sampling design. Sampling weights were used in the analysis to adjust for the bias introduced by the stratified sampling. Inner-city maternity service, South London. 545 pregnant women were interviewed after their first antenatal appointment; 528 provided answers on the GAD-2 questions. Diagnosis generated by the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition (SCID). Population prevalence of anxiety disorders was 17% (95% CI 12% to 21%): 5% (95% CI 3% to 6%) for GAD, 4% (95% CI 2% to 6%) for social phobia, 8% (95% CI 5% to 11%) for specific phobia and 2% (95% CI 1% to 4%) for obsessive-compulsive disorder. Post-traumatic stress disorder (PTSD) prevalence was unclear due to higher levels of reluctance to respond to PTSD interview questions but sensitivity analyses suggest population prevalence maybe up to 4% (95% CI 2% to 6%). Weighted sensitivity of GAD-2 for GAD (cut-off ≥3) was 69%, specificity 91%, positive predictive value 26%, negative predictive value 98% and likelihood ratio 7.35. For any anxiety disorder the weighted sensitivity was 26%, specificity 91%, positive predictive value 36%, negative predictive value 87% and likelihood ratio 2.92. Anxiety disorders are common but GAD-2 generates many false positives and may therefore be unhelpful in maternity services.
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DOI：
10.1161/circoutcomes.111.000049
发表时间：
2013-07-01
影响因子：
6.9
作者：
Celano, Christopher M.;Suarez, Laura;Huffman, Jeff C.
通讯作者：
Huffman, Jeff C.
影响因子：
6.6
作者：
Martini, Julia;Petzoldt, Johanna;Wittchen, Hans-Ulrich
通讯作者：
Wittchen, Hans-Ulrich
影响因子：
3.1
作者：
Kessler, Ronald C.;Petukhova, Maria;Sampson, Nancy A.;Zaslavsky, Alan M.;Wittchen, Hans-Ullrich
通讯作者：
Wittchen, Hans-Ullrich
影响因子：
17.7
作者：
Kelly, RH;Danielson, BH;Burt, VK
通讯作者：
Burt, VK
影响因子：
6.6
作者：
Matthey, Stephen;Fisher, Jane;Rowe, Heather
通讯作者：
Rowe, Heather