Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States.

Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States.
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DOI:
10.1002/mpr.1359
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发表时间:
2012-09
影响因子:
3.1
通讯作者:
Wittchen, Hans-Ullrich
Wittchen, Hans-Ullrich
中科院分区:
医学3区
文献类型:
--
作者:
Kessler, Ronald C.;Petukhova, Maria;Sampson, Nancy A.;Zaslavsky, Alan M.;Wittchen, Hans-Ullrich

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根据美国13岁以上人群的流行病学调查,提供了精神疾病诊断和统计手册第四版文本修订版(DSM-IV-TR)焦虑和心境障碍的12个月和终生患病率以及终生患病风险(LMR)估计值。该演示文稿旨在用于即将出版的DSM-5手册,以提供比其他方式更一致的估计。DSM-5工作组提出的年龄组的患病率估计数是最有用的考虑政策规划的目的。按频率排列的LMR/12个月患病率估计值如下:重度抑郁发作:29.9%/8.6%;特定恐怖症:18.4/12.1%;社交恐怖症:13.0/7.4%;创伤后应激障碍:10.1/3.7%;广泛性焦虑症:9.0/2.0%;分离焦虑症:8.7/1.2%;惊恐障碍:6.8%/2.4%;双相情感障碍:4.1/1.8%;广场恐怖症:3.7/1.7%;强迫症:2.7/1.2。最值得注意的是四种广泛的结果模式:首先,最常见的(终生患病率/病态风险)美国终生焦虑情绪障碍是重度抑郁症(16.6/29.9%),特定恐怖症(15.6/18.4%),社交恐惧症(10.7/13.0%),最不常见的是广场恐怖症(2.5/3.7%)和强迫症(2.3/2.7%);第二,中位发病年龄较早的焦虑情绪障碍是恐惧症和分离焦虑症(15-17岁)和那些最新的恐慌症,严重抑郁症,广泛性焦虑症(23-30岁);第三,对于大多数焦虑情绪障碍,LMR远高于终生患病率,尽管对于发病年龄晚于早期的障碍,这种差异的幅度要高得多;第四,12个月患病率与终生患病率的比率,大致表征了持续性,其变化方式有意义,与关于这些疾病不同持续性的独立证据一致。
Estimates of 12-month and lifetime prevalence and of lifetime morbid risk (LMR) of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) anxiety and mood disorders are presented based on US epidemiological surveys among people aged 13+. The presentation is designed for use in the upcoming DSM-5 manual to provide more coherent estimates than would otherwise be available. Prevalence estimates are presented for the age groups proposed by DSM-5 workgroups as the most useful to consider for policy planning purposes. The LMR/12-month prevalence estimates ranked by frequency are as follows: major depressive episode: 29.9%/8.6%; specific phobia: 18.4/12.1%; social phobia: 13.0/7.4%; post-traumatic stress disorder: 10.1/3.7%; generalized anxiety disorder: 9.0/2.0%; separation anxiety disorder: 8.7/1.2%; panic disorder: 6.8%/2.4%; bipolar disorder: 4.1/1.8%; agoraphobia: 3.7/1.7%; obsessive-compulsive disorder: 2.7/1.2. Four broad patterns of results are most noteworthy: first, that the most common (lifetime prevalence/morbid risk) lifetime anxiety-mood disorders in the United States are major depression (16.6/29.9%), specific phobia (15.6/18.4%), and social phobia (10.7/13.0%) and the least common are agoraphobia (2.5/3.7%) and obsessive-compulsive disorder (2.3/2.7%); second, that the anxiety-mood disorders with the earlier median ages-of-onset are phobias and separation anxiety disorder (ages 15-17) and those with the latest are panic disorder, major depression, and generalized anxiety disorder (ages 23-30); third, that LMR is considerably higher than lifetime prevalence for most anxiety-mood disorders, although the magnitude of this difference is much higher for disorders with later than earlier ages-of-onset; and fourth, that the ratio of 12-month to lifetime prevalence, roughly characterizing persistence, varies meaningfully in ways consistent with independent evidence about differential persistence of these disorders.
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