How does antiretroviral treatment attenuate the stigma of HIV? Evidence from a cohort study in rural Uganda.
How does antiretroviral treatment attenuate the stigma of HIV? Evidence from a cohort study in rural Uganda.
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DOI：
10.1007/s10461-013-0503-3
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发表时间：
2013-10
影响因子：
4.4
通讯作者：
Weiser, Sheri D.
中科院分区：
文献类型：
--
作者：
Tsai, Alexander C.;Bangsberg, David R.;Bwana, Mwebesa;Haberer, Jessica E.;Frongillo, Edward A.;Muzoora, Conrad;Kumbakumba, Elias;Hunt, Peter W.;Martin, Jeffrey N.;Weiser, Sheri D.
方案执行者和定性研究人员描述了艾滋病毒抗逆转录病毒治疗（ART）的增加与心理社会健康和内化耻辱的改善之间的关系。为了确定ART是否以及通过什么渠道减少内化的耻辱感，我们分析了乌干达农村262名艾滋病毒感染者的数据，这些人在ART开始后的中位数为3.4年。我们拟合泊松回归模型与集群相关的稳健的方差估计，指定内化的耻辱作为因变量，调整治疗时间以及社会人口统计学，临床和心理社会变量。随着治疗时间的推移，内化的耻辱感稳步下降，在治疗的头两年观察到最大的下降。在多变量调整后，这一趋势仍具有统计学显著性（χ2=28.3; p=0.03），似乎是由ART诱导的HIV症状负担、身心健康和抑郁症状严重程度的改善驱动的。
Program implementers and qualitative researchers have described how increasing availability of HIV antiretroviral therapy (ART) is associated with improvements in psychosocial health and internalized stigma. To determine whether, and through what channels, ART reduces internalized stigma, we analyzed data from 262 HIV-infected, treatment-naïve persons in rural Uganda followed from ART initiation over a median of 3.4 years. We fitted Poisson regression models with cluster-correlated robust estimates of variance, specifying internalized stigma as the dependent variable, adjusting for time on treatment as well as socio-demographic, clinical, and psychosocial variables. Over time on treatment, internalized stigma declined steadily, with the largest decline observed during the first two years of treatment. This trend remained statistically significant after multivariable adjustment (χ2=28.3; p=0.03), and appeared to be driven by ART-induced improvements in HIV symptom burden, physical and psychological wellbeing, and depression symptom severity.
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影响因子：
3.3
作者：
Muhamadi, Lubega;Nsabagasani, Xavier;Pariyo, George
通讯作者：
Pariyo, George
DOI：
10.1002/bs.3830190102
发表时间：
1974-01-01
期刊：
BEHAVIORAL SCIENCE
影响因子：
--
作者：
DEROGATIS, LR;LIPMAN, RS;COVI, L
通讯作者：
COVI, L
影响因子：
3.5
作者：
Filmer, D;Pritchett, LH
通讯作者：
Pritchett, LH
影响因子：
1.9
作者：
Bolton, P
通讯作者：
Bolton, P
影响因子：
2.4
作者：
Gilbert, Leah;Walker, Liz
通讯作者：
Walker, Liz