Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness.
Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness.
复制标题
独特且可分离的脑电图网络与麻醉引起的无意识后认知功能的恢复有关。
DOI：
10.3389/fnhum.2021.706693
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发表时间：
2021
影响因子：
2.9
通讯作者：
Blain-Moraes S
中科院分区：
文献类型：
--
作者：
Rokos A;Mišić B;Berkun K;Duclos C;Tarnal V;Janke E;Picton P;Golmirzaie G;Basner M;Avidan MS;Kelz MB;Mashour GA;Blain-Moraes S
意识大扰动后认知功能恢复的时间轨迹和神经机制是临床和神经科学的兴趣。本研究的目的是调查网络水平的功能性脑连接的变化与恢复和恢复的六个认知功能全身麻醉后。记录了接受临床相关麻醉方案（丙泊酚诱导和异氟烷维持）的健康志愿者和年龄匹配的健康对照者的高密度脑电图（EEG）。一组认知测试（运动实践，视觉对象学习测试，分形-2-回，抽象匹配，精神警觉性测试，数字符号替代测试）在基线时，意识恢复（ROC）后，并在半小时的时间间隔，直到3小时后ROC。通过加权相位滞后指数（wPLI）测量功能连接的强度，来自EEG网络。进行偏最小二乘（PLS）分析以评估这些网络的变化：（1）麻醉组和对照组之间;（2）麻醉恢复3小时期间;（3）麻醉恢复期间的每项认知测试。在ROC后，网络受到最大程度的干扰，但在ROC后30-60分钟恢复到基线，尽管认知能力的缺陷在ROC后持续3小时。此外，在麻醉恢复期间，在同一时间点进行的认知测试激活了所有频带上不同且可分离的功能连接网络。结果强调，麻醉诱导的无意识后认知功能的恢复是特定于任务的，具有独特的行为和大脑网络恢复轨迹。
The temporal trajectories and neural mechanisms of recovery of cognitive function after a major perturbation of consciousness is of both clinical and neuroscientific interest. The purpose of the present study was to investigate network-level changes in functional brain connectivity associated with the recovery and return of six cognitive functions after general anesthesia. High-density electroencephalograms (EEG) were recorded from healthy volunteers undergoing a clinically relevant anesthesia protocol (propofol induction and isoflurane maintenance), and age-matched healthy controls. A battery of cognitive tests (motor praxis, visual object learning test, fractal-2-back, abstract matching, psychomotor vigilance test, digital symbol substitution test) was administered at baseline, upon recovery of consciousness (ROC), and at half-hour intervals up to 3 h following ROC. EEG networks were derived using the strength of functional connectivity measured through the weighted phase lag index (wPLI). A partial least squares (PLS) analysis was conducted to assess changes in these networks: (1) between anesthesia and control groups; (2) during the 3-h recovery from anesthesia; and (3) for each cognitive test during recovery from anesthesia. Networks were maximally perturbed upon ROC but returned to baseline 30–60 min following ROC, despite deficits in cognitive performance that persisted up to 3 h following ROC. Additionally, during recovery from anesthesia, cognitive tests conducted at the same time-point activated distinct and dissociable functional connectivity networks across all frequency bands. The results highlight that the return of cognitive function after anesthetic-induced unconsciousness is task-specific, with unique behavioral and brain network trajectories of recovery.
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影响因子：
8.8
作者：
Blain-Moraes S;Tarnal V;Vanini G;Alexander A;Rosen D;Shortal B;Janke E;Mashour GA
通讯作者：
Mashour GA
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影响因子：
2.9
作者：
Blain-Moraes S;Tarnal V;Vanini G;Bel-Behar T;Janke E;Picton P;Golmirzaie G;Palanca BJA;Avidan MS;Kelz MB;Mashour GA
通讯作者：
Mashour GA