Aging and dry eye disease.

Aging and dry eye disease.
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DOI:
10.1016/j.exger.2012.03.020
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发表时间:
2012-07
影响因子:
3.9
通讯作者:
Sullivan, David A.
Sullivan, David A.
中科院分区:
医学2区
文献类型:
--
作者:
Ding, Juan;Sullivan, David A.

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干眼病是一种常见的眼部疾病,尤其影响老年人。干眼症的主要原因之一,睑板腺功能障碍(MGD),随着年龄的增长而增加。MGD是由睑板腺导管上皮角化过度和睑板数量和/或质量减少引起的,睑板是稳定和防止泪膜蒸发的全息产物。值得注意的是,目前抗衰老化妆品中使用的类维生素a可能会促进MGD和干眼病的发展。在这篇综述中,我们将讨论与年龄相关的MGD的可能机制。
Dry eye disease is a prevalent eye disorder that in particular affects the elderly population. One of the major causes of dry eye, meibomian gland dysfunction (MGD), shows increased prevalence with aging. MGD is caused by hyperkeratinization of the ductal epithelium of meibomian gland and reduced quantity and/or quality of meibum, the holocrine product that stabilizes and prevents the evaporation of the tear film. Of note, retinoids which are used in current anti-aging cosmetics may promote the development of MGD and dry eye disease. In this review, we will discuss the possible mechanisms of age-related MGD.
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