Aging and dry eye disease.
Aging and dry eye disease.
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DOI:
10.1016/j.exger.2012.03.020
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发表时间:
2012-07
影响因子:
3.9
通讯作者:
Sullivan, David A.
中科院分区:
文献类型:
--
作者:
Ding, Juan;Sullivan, David A.
关键词:
Dry eye disease is a prevalent eye disorder that in particular affects the elderly population. One of the major causes of dry eye, meibomian gland dysfunction (MGD), shows increased prevalence with aging. MGD is caused by hyperkeratinization of the ductal epithelium of meibomian gland and reduced quantity and/or quality of meibum, the holocrine product that stabilizes and prevents the evaporation of the tear film. Of note, retinoids which are used in current anti-aging cosmetics may promote the development of MGD and dry eye disease. In this review, we will discuss the possible mechanisms of age-related MGD.
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