Rapid desensitization of substance P- but not carbachol-induced increases in inositol trisphosphate and intracellular Ca++ in rat parotid acinar cells.
Rapid desensitization of substance P- but not carbachol-induced increases in inositol trisphosphate and intracellular Ca++ in rat parotid acinar cells.
复制标题
P 物质快速脱敏，但不诱导大鼠腮腺腺泡细胞中三磷酸肌醇和细胞内 Ca 的增加。
DOI：
10.1016/s0006-291x(87)80233-4
复制
发表时间：
1987
影响因子：
3.1
通讯作者：
B. Talamo
中科院分区：
文献类型：
--
作者：
M. McMillian;S. Soltoff;B. Talamo
在大鼠腮腺腺泡细胞中，比较了P物质和胆碱能激动剂卡巴胆碱的最大浓度对三磷酸肌醇积累和细胞内游离钙浓度升高的影响。P物质在初始时间完全与卡巴胆碱一样有效，但P物质反应迅速丧失，而卡巴胆碱的效果保持良好。P物质反应的丧失代表肽的脱敏而不是降解，因为进一步添加P物质没有效果。对P物质的脱敏并不涉及P物质受体的长期损失，因为它在不到20分钟的时间内完全可逆，这是广泛清洗先前脱敏细胞的最短时间。
The effects of supramaximal concentrations of substance P and the cholinergic agonist carbachol on the accumulation of inositol trisphosphate and the elevation of the intracellular free calcium concentration were compared in rat parotid acinar cells. Substance P was fully as effective as carbachol at initial times, but there was a rapid loss of the substance P responses while the effects of carbachol were well maintained. The loss of the substance P responses represented desensitization rather than degradation of the peptide since further additions of substance P were without effect. Desensitization to substance P did not involve long-term loss of substance P receptors as it was fully reversible in less than twenty minutes, the minimum time to extensively wash previously desensitized cells.
大鼠腮腺腺泡细胞胆碱能反应的α-肾上腺素能调节。
影响因子：
3.6
作者：
Davis,JN;Olender,E;Maury,W;McDaniel,R
通讯作者：
McDaniel,R
鸟嘌呤核苷酸依赖性调节蛋白将大鼠腮腺中的 P 物质受体与磷脂酶 C 偶联。
DOI：
10.1016/0006-291x(86)90919-8
发表时间：
1986
影响因子：
3.1
作者：
Taylor,CW;Merritt,JE;PutneyJr,JW;Rubin,RP
通讯作者：
Rubin,RP