Hippocampal and Prefrontal Cortical Brain Tissue Levels of Irisin and GDF15 Receptor Subunits in Children.
Hippocampal and Prefrontal Cortical Brain Tissue Levels of Irisin and GDF15 Receptor Subunits in Children.
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DOI：
10.1007/s12035-020-02250-4
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发表时间：
2021-05
影响因子：
5.1
通讯作者：
Kochanek PM
中科院分区：
文献类型：
--
作者：
Jackson TC;Gorse K;Herrmann JR;Kochanek PM
冷应激激素（CSHs）刺激产热，对大脑有直接的神经保护作用。最近发现了两种新的CSH（irisin和生长分化因子-15 [GDF 15]）的专性受体组分。鸢尾素结合整联蛋白-αV/β5异二聚体，而GDF-15结合孤儿受体胶质细胞源性神经营养因子（GDNF）家族受体α样（GFRAL）。此外，整合素-αV/β5刚刚被确定为介导中枢神经系统寨卡病毒感染的关键受体。我们测量了婴儿、幼儿、学龄前儿童、青少年和成人的78个高质量人类男性/女性脑组织中的整合素-αV、整合素-β5和GFRAL蛋白水平，提供了迄今为止对人类皮层和海马中整合素-αV、整合素-β5和GFRAL蛋白水平最可靠的分析。我们报告说，整合素-αV在所有年龄的前额叶皮层中检测到的水平最高的成年人。整合素-αV在各年龄组的海马中也有表达。相比之下，在皮质和海马中检测到整合素-β5主要限于婴儿。整合素-αV/β5在人类婴儿海马和皮质中的共表达表明，鸢尾素对发育中的大脑比成人大脑具有更强大的影响，可能对婴儿和幼儿的寨卡病毒感染有影响。在线版本包含补充材料，可通过10.1007/s12035-020-02250-4获得。
Cold-stress hormones (CSHs) stimulate thermogenesis and have direct neuroprotective effects on the brain. The obligatory receptor components of two new CSHs (irisin and growth differentiation factor-15 [GDF15]) were recently discovered. Irisin binds integrin-αV/β5 heterodimers while GDF-15 binds to the orphan receptor glial cell-derived neurotrophic factor (GDNF) family receptor α-like (GFRAL). In addition, integrin-αV/β5 was just identified as the key receptor mediating Zika virus infection in the CNS. We measured integrin-αV, integrin-β5, and GFRAL protein levels across 78 high-quality human male/female brain tissues in infants, toddlers, preschoolers, adolescent, and adults—providing the most robust analysis to date on their levels in the human cortex and hippocampus. We report that integrin-αV was detected at all ages in the prefrontal cortex with levels greatest in adults. Integrin-αV was also detected in the hippocampus in all age groups. In contrast, integrin-β5 was detected in cortex and hippocampus largely restricted to infants. Co-expression of integrin-αV/β5 in the human infant hippocampus and cortex suggests the possibility that irisin has a more robust effect on the developing vs. the adult brain and may have implications for Zika virus infection in infants and young children. The online version contains supplementary material available at 10.1007/s12035-020-02250-4.
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影响因子：
82.9
作者：
Emmerson, Paul J.;Wang, Feng;Wu, Xinle
通讯作者：
Wu, Xinle
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
7.5
作者：
Jin, Zhao;Guo, Peipei;Wu, Huisheng
通讯作者：
Wu, Huisheng
影响因子：
6.3
作者：
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通讯作者：
Jansen, Olav
DOI：
10.1016/j.metabol.2015.07.019
发表时间：
2015-11
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Joung KE;Park KH;Filippaios A;Dincer F;Christou H;Mantzoros CS
通讯作者：
Mantzoros CS