Experimental and phylogenetic evidence for correlated gene expression evolution in endometrial and skin fibroblasts.
Experimental and phylogenetic evidence for correlated gene expression evolution in endometrial and skin fibroblasts.
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DOI：
10.1016/j.isci.2023.108593
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发表时间：
2024-01-19
期刊：
影响因子：
5.8
通讯作者：
Wagner, Gunter P.
中科院分区：
文献类型：
--
作者：
Dighe, Anasuya;Maziarz, Jamie;Ibrahim-Hashim, Arig;Gatenby, Robert A.;Kshitiz;Levchenko, Andre;Wagner, Gunter P.
基因表达变化是进化的主导模式。然而，突变可以影响多种细胞类型中的基因表达。因此，一种细胞类型中的基因表达进化可以导致另一种细胞类型中的类似基因表达变化。在这里，我们通过研究真皮皮肤成纤维细胞（SF）和子宫内膜间质成纤维细胞（ESFs）来验证这一假设。比较数据集由9种哺乳动物的培养SF和ESF的转录组组成。我们发现SF和ESF基因表达的进化变化高度相关。实验数据集来源于选择用于缓慢癌症生长的SCID小鼠品系，导致SF中的大量基因表达变化。我们比较了SF和ESF的基因表达谱，发现它们之间存在显著的相关性。我们讨论了这些发现的意义胎盘侵袭性和转移性癌症的脆弱性之间的进化相关性。SFs和ESFs中的进化基因表达变化高度相关SFs中基因表达的选择导致ESFs中相关的基因表达变化这些发现解释了胎盘类型和癌症恶性肿瘤之间的共同进化生物学;系统发生学;细胞生物学;表达研究;癌症
Gene expression change is a dominant mode of evolution. Mutations, however, can affect gene expression in multiple cell types. Therefore, gene expression evolution in one cell type can lead to similar gene expression changes in another cell type. Here, we test this hypothesis by investigating dermal skin fibroblasts (SFs) and uterine endometrial stromal fibroblasts (ESFs). The comparative dataset consists of transcriptomes from cultured SF and ESF of nine mammalian species. We find that evolutionary changes in gene expression in SF and ESF are highly correlated. The experimental dataset derives from a SCID mouse strain selected for slow cancer growth leading to substantial gene expression changes in SFs. We compared the gene expression profiles of SF with that of ESF and found a significant correlation between them. We discuss the implications of these findings for the evolutionary correlation between placental invasiveness and vulnerability to metastatic cancer. Evolutionary gene expression changes in SFs and ESFs are highly correlated Selection on gene expression in SFs leads to correlated gene expression changes in ESFs These findings explain the co-evolution between placenta type and cancer malignancy Evolutionary biology; Phylogeny; Cell biology; Expression study; Cancer
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影响因子：
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作者：
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通讯作者：
Gatenby RA