Low expression of H3K27me3 is associated with poor prognosis in conventional chordoma.
Low expression of H3K27me3 is associated with poor prognosis in conventional chordoma.
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H3K27me3 的低表达与传统脊索瘤的不良预后相关
DOI：
10.3389/fonc.2022.1048482
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发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
脊索瘤是一种罕见的局部侵袭性肿瘤，预后因素有限。组蛋白3赖氨酸27(H3K27)三甲基化(H3K27me3)的缺失被认为与某些肿瘤的预后不良有关。本研究的目的是检测H3K27me3在脊索瘤中的表达，分析其与临床病理特征的相关性，探讨H3K27me3作为潜在的预后标志物和治疗靶点的作用。应用组织芯片技术对162例脊索瘤患者(包括156例常规脊索瘤、4例去分化脊索瘤和2例低分化脊索瘤)进行H3K27me3抗体免疫组织化学染色。分析H3K27me3的表达与临床病理特征的关系。对患者的临床资料进行相关分析，并进行生存分析。采用Kaplan-Meier生存曲线和对数列检验分析患者的无复发生存率(RFS)和总生存率(OS)。多因素COX回归分析用于确定潜在的预后因素。H3K27me3在37例脊索瘤患者中低表达(37/162，22.8%)，125例高表达(125/162，77.2%)。H3K27me3-低表达与脊柱部位(P<；0.001)、传统组织学亚型(P<；0.001)和复发(P<；0.001)显著相关。LOG-RANK检验显示，在传统脊索瘤患者中，H3K27me3低表达与RFS(P=0.027)和OS(P=0.009)低相关。COX多因素分析显示，H3K27me3低表达是传统脊索瘤患者不良OS(P=0.007)和RF(P=0.025)的独立预测因素。我们的研究表明，H3K27me3的低表达可能是预后不良和复发的预测因素，它可能为传统脊索瘤患者提供一个潜在的治疗靶点。
Chordoma is a rare and locally invasive neoplasm, and the prognostic factors are limited. Deregulation of Histone 3 lysine 27 (H3K27) trimethylation (H3K27me3) is considered to be related with poor prognosis in some tumors. The purpose of this study was to detect the expression of H3K27me3 in chordomas and analyze the correlation with clinicopathological features and explore the roles as potential prognostic markers and therapeutic targets. Specimens of 162 chordoma patients (consisting of 156 conventional chordoma, 4 dedifferentiated chordoma and 2 poorly differentiated chordoma) were enrolled in a tissue microarray (TMA) in order to assess the immunohistochemical staining by H3K27me3 antibodies. Correlations between H3K27me3 expression and clinicopathological features were analyzed. Clinical data of the patients were correlated and survival analysis was performed. Kaplan-Meier survival curves and log-rank test were used to analyze the recurrence-free survival (RFS) and overall survival (OS). Multivariate Cox regression analyses were used to identify potential prognostic factors. The expression of H3K27me3 was lower in 37 chordoma patients (37/162, 22.8%), and higher in 125 patients (125/162, 77.2%). H3K27me3-low expression significantly correlated with spine location (P < 0.001), conventional histological subtype (P < 0.001), and recurrence (P < 0.001). Log-rank test showed that H3K27me3-low expression was associated with poor RFS (P =0.027) and OS (P =0.009) in conventional chordoma patients. Cox multivariate analysis revealed that low expression of H3K27me3 was an independent predictor of poor OS (P =0.007) and RFS (P =0.025) in conventional chordoma patients. Our study indicates that low expression of H3K27me3 might be considered as a predictor for poor prognosis and recurrence, and it may provide a potential therapeutic target for conventional chordoma patients.
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影响因子：
2.6
作者：
Pan Y;Lu L;Chen J;Zhong Y;Dai Z
通讯作者：
Dai Z
DOI：
10.1016/j.wjorl.2015.09.005
发表时间：
2015-09
期刊：
World journal of otorhinolaryngology - head and neck surgery
影响因子：
--
作者：
Liu JQ;Zhang QH;Wang ZL
通讯作者：
Wang ZL
影响因子：
3.2
作者：
Gauchotte, Guillaume;Peyre, Matthieu;Bielle, Franck
通讯作者：
Bielle, Franck
影响因子：
11.2
作者：
Cottone, Lucia;Cribbs, Adam P.;Flanagan, Adrienne M.
通讯作者：
Flanagan, Adrienne M.
影响因子：
3.2
作者：
Chanplakorn, Pongsthorn;Lertudomphonwanit, Thamrong;Laohacharoensombat, Wichien
通讯作者：
Laohacharoensombat, Wichien