Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis.
Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis.
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DOI：
10.1001/jamapsychiatry.2014.2502
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发表时间：
2015-04
期刊：
影响因子：
25.8
通讯作者：
Druss, Benjamin G.
中科院分区：
文献类型：
--
作者：
Walker, Elizabeth Reisinger;McGee, Robin E.;Druss, Benjamin G.
尽管了解精神障碍患者的超额死亡率具有潜在的重要性，但尚未进行全面的荟萃分析来量化精神障碍患者的死亡率。对精神障碍患者的死亡率进行系统回顾和荟萃分析，并检查死亡类型，诊断和研究特征的死亡风险差异。我们检索了EMBASE、MEDLINE、PsychINFO和Web of Science从开始到2014年5月7日，包括合格文章的参考文献。我们的检索策略包括精神障碍（例如，精神障碍、严重精神疾病和严重精神疾病）、特定诊断（例如，精神分裂症、抑郁症、焦虑症和双相情感障碍）和死亡率。我们还使用Google Scholar来识别引用了合格文章的文章。纳入了英语队列研究，这些研究报告了与普通人群或来自相同研究环境的无精神疾病对照组相比的精神疾病死亡率估计值。两名评审员独立评审了标题、摘要和文章。在识别的2481项研究中，203篇文章符合合格标准，代表6大洲的29个国家。一名评审员对所有数据进行了全面抽象，2名评审员验证了准确性。死亡率估计（例如，标准化死亡率比，相对风险，风险比，比值比和潜在寿命损失年数）比较精神障碍患者和普通人群或无精神障碍的人。我们使用随机效应荟萃分析模型来汇总所有、自然和非自然死亡原因的死亡率。我们还检查了潜在寿命损失的年数，并估计了因精神障碍导致死亡的人群归因风险。对于全因死亡率，精神障碍患者（来自148项研究）的合并死亡相对风险为2.22（95%CI，2.12-2.33）。其中，135项研究显示，精神障碍患者的死亡率明显高于对照人群。在精神障碍患者中，共有67.3%的死亡是由于自然原因，17.5%是由于非自然原因，其余的是由于其他原因或未知原因。潜在寿命损失的中位数为10年（n = 24项研究）。我们估计，全世界14.3%的死亡，即每年约800万人的死亡，可归因于精神障碍。这些估计数表明，精神障碍是全世界最主要的死亡原因之一。量化和解决全球疾病负担的努力需要更好地考虑精神障碍在可预防死亡率中的作用。
Despite the potential importance of understanding excess mortality among people with mental disorders, no comprehensive meta-analyses have been conducted quantifying mortality across mental disorders. To conduct a systematic review and meta-analysis of mortality among people with mental disorders and examine differences in mortality risks by type of death, diagnosis, and study characteristics. We searched EMBASE, MEDLINE, PsychINFO, and Web of Science from inception through May 7, 2014, including references of eligible articles. Our search strategy included terms for mental disorders (eg, mental disorders, serious mental illness, and severe mental illness), specific diagnoses (eg, schizophrenia, depression, anxiety, and bipolar disorder), and mortality. We also used Google Scholar to identify articles that cited eligible articles. English-language cohort studies that reported a mortality estimate of mental disorders compared with a general population or controls from the same study setting without mental illness were included. Two reviewers independently reviewed the titles, abstracts, and articles. Of 2481 studies identified, 203 articles met the eligibility criteria and represented 29 countries in 6 continents. One reviewer conducted a full abstraction of all data, and 2 reviewers verified accuracy. Mortality estimates (eg, standardized mortality ratios, relative risks, hazard ratios, odds ratios, and years of potential life lost) comparing people with mental disorders and the general population or people without mental disorders. We used random-effects meta-analysis models to pool mortality ratios for all, natural, and unnatural causes of death. We also examined years of potential life lost and estimated the population attributable risk of mortality due to mental disorders. For all-cause mortality, the pooled relative risk of mortality among those with mental disorders (from 148 studies) was 2.22 (95% CI, 2.12–2.33). Of these, 135 studies revealed that mortality was significantly higher among people with mental disorders than among the comparison population. A total of 67.3% of deaths among people with mental disorders were due to natural causes, 17.5% to unnatural causes, and the remainder to other or unknown causes. The median years of potential life lost was 10 years (n = 24 studies). We estimate that 14.3% of deaths worldwide, or approximately 8 million deaths each year, are attributable to mental disorders. These estimates suggest that mental disorders rank among the most substantial causes of death worldwide. Efforts to quantify and address the global burden of illness need to better consider the role of mental disorders in preventable mortality.
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影响因子：
9.7
作者：
Milstein, Bobby;Homer, Jack;Pechacek, Terry
通讯作者：
Pechacek, Terry
精神障碍的负担。
影响因子：
5.5
作者：
Eaton WW;Martins SS;Nestadt G;Bienvenu OJ;Clarke D;Alexandre P
通讯作者：
Alexandre P
DOI：
10.1146/annurev-clinpsy-032813-153657
发表时间：
2014-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 10
影响因子：
--
作者：
Laursen, Thomas Munk;Nordentoft, Merete;Mortensen, Preben Bo
通讯作者：
Mortensen, Preben Bo
影响因子：
17.7
作者：
Cuijpers, Pim;Vogelzangs, Nicole;Penninx, Brenda W.
通讯作者：
Penninx, Brenda W.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N