Connexin Gap Junctions and Hemichannels Link Oxidative Stress to Skeletal Physiology and Pathology.
Connexin Gap Junctions and Hemichannels Link Oxidative Stress to Skeletal Physiology and Pathology.
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DOI：
10.1007/s11914-020-00645-9
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发表时间：
2021-03
影响因子：
4.3
通讯作者：
Jiang JX
中科院分区：
文献类型：
--
作者：
Hua R;Zhang J;Riquelme MA;Jiang JX
本文综述了氧化应激对连接蛋白通道功能的影响及其机制，以及它们在骨骼衰老、雌激素缺乏和糖皮质激素过量相关的骨丢失中的作用。连接蛋白半通道开放在氧化应激条件下增加，其赋予细胞保护作用以对抗氧化应激诱导的细胞死亡。氧化应激是衰老、雌激素缺乏和糖皮质激素过量诱导的骨质疏松症的关键因素，并损害骨细胞网络和连接蛋白间隙连接通讯。本文综述了氧化应激和连接蛋白通道在骨质疏松症发病机制中的作用以及连接蛋白通道对氧化应激的生理和病理反应。氧化应激降低骨细胞活力，破坏合成代谢和分解代谢反应的平衡。连接蛋白43（Cx43）通道在骨重建、机械传导和骨细胞存活中起关键作用。在氧化应激条件下，Cx43表达持续减少，而Cx43半通道的开放保护骨细胞免受氧化应激引起的细胞损伤。
The goal of this review is to provide an overview of the impact and underlying mechanism of oxidative stress on connexin channel function, and their roles in skeletal aging, estrogen deficiency, and glucocorticoid excess associated bone loss. Connexin hemichannel opening is increased under oxidative stress conditions, which confers a cell protective role against oxidative stress-induced cell death. Oxidative stress acts as a key contributor to aging, estrogen deficiency, and glucocorticoid excess-induced osteoporosis and impairs osteocytic network and connexin gap junction communication. This paper reviews the current knowledge for the role of oxidative stress and connexin channels in the pathogenesis of osteoporosis and physiological and pathological responses of connexin channels to oxidative stress. Oxidative stress decreases osteocyte viability and impairs the balance of anabolic and catabolic responses. Connexin 43 (Cx43) channels play a critical role in bone remodeling, mechanotransduction, and survival of osteocytes. Under oxidative stress conditions, there is a consistent reduction of Cx43 expression, while the opening of Cx43 hemichannels protects osteocytes against cell injury caused by oxidative stress.
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影响因子：
7.8
作者：
Davis HM;Pacheco-Costa R;Atkinson EG;Brun LR;Gortazar AR;Harris J;Hiasa M;Bolarinwa SA;Yoneda T;Ivan M;Bruzzaniti A;Bellido T;Plotkin LI
通讯作者：
Plotkin LI
影响因子：
11.4
作者：
Chi, Yuan;Zhang, Xiling;Zhang, Zhen;Mitsui, Takahiko;Kamiyama, Manabu;Takeda, Masayuki;Yao, Jian
通讯作者：
Yao, Jian
影响因子：
4.2
作者：
Bellido, Teresita
通讯作者：
Bellido, Teresita
影响因子：
3.3
作者：
Cherian, PP;Siller-Jackson, AJ;Jiang, JX
通讯作者：
Jiang, JX
影响因子：
4.4
作者：
Hutnik, Cindy M. L.;Pocrnich, Cady E.;Shao, Qing
通讯作者：
Shao, Qing