From support to therapy: rethinking the role of nutrition in acute graft-versus-host disease.
From support to therapy: rethinking the role of nutrition in acute graft-versus-host disease.
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DOI：
10.3389/fimmu.2023.1192084
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
异基因造血干细胞移植（HSCT）为恶性血液病患者提供了一种潜在的治疗方法。不幸的是，移植物抗宿主病（GVHD）仍然是这种治疗取得更大成功的主要障碍。尽管在过去的几十年里进行了深入的研究，GVHD仍然是接受同种异体HSCT的患者发病率和死亡率的主要原因。供体和受体之间的遗传差异是决定同种免疫应答程度和急性GVHD（aGVHD）严重程度的主要因素。然而，一些非遗传因素也积极参与GVHD的发病机制。因此，识别可以容易地被修饰以降低GVHD风险的宿主因素具有重要的临床意义。我们特别感兴趣的是营养的潜在作用，作为一个非遗传因素，在aGVHD的病因和管理。在这篇文章中，我们总结了最近的研究结果，关于不同途径的营养支持和各种饮食因素如何影响aGVHD。由于饮食是形成肠道微生物群的最重要因素之一，我们还提供了某些营养素与同种异体HSCT接受者肠道微生物群之间潜在联系的证据。我们建议通过靶向肠道微生物群，将营养的作用从支持转移到GVHD的治疗。
Allogeneic Hematopoietic stem cell transplantation (HSCT) offers a potential cure for patients with hematologic malignancies. Unfortunately, graft-versus-host disease (GVHD) remains a major obstacle to the greater success of this treatment. Despite intensive research efforts over the past several decades, GVHD is still a major cause of morbidity and mortality in patients receiving allogeneic HSCT. The genetic disparity between donor and recipient is the primary factor that dictates the extent of alloimmune response and the severity of acute GVHD (aGVHD). However, some nongenetic factors are also actively involved in GVHD pathogenesis. Thus, identifying host factors that can be readily modified to reduce GVHD risk is of important clinical significance. We are particularly interested in the potential role of nutrition, as a nongenetic factor, in the etiology and management of aGVHD. In this article, we summarize recent findings regarding how different routes of nutritional support and various dietary factors affect aGVHD. Since diet is one of the most important factors that shape gut microbiota, we also provide evidence for a potential link between certain nutrients and gut microbiota in recipients of allogeneic HSCT. We propose a shifting role of nutrition from support to therapy in GVHD by targeting gut microbiota.
影响因子：
3.7
作者：
Koenecke C;Prinz I;Bubke A;Schreder A;Lee CW;Pabst O;Förster R
通讯作者：
Förster R
DOI：
10.31547/bct-2021-024
发表时间：
2022-05-25
期刊：
Blood cell therapy
影响因子：
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作者：
Fuji, Shigeo;Cheng, Jessica;Yakushijin, Kimikazu;Wanitpongpun, Chinadol
通讯作者：
Wanitpongpun, Chinadol