Polymorphisms in CYP17 and CYP3A4 and prostate cancer in men of African descent.
Polymorphisms in CYP17 and CYP3A4 and prostate cancer in men of African descent.
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DOI：
10.1002/pros.22612
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发表时间：
2013-05
期刊：
影响因子：
2.8
通讯作者：
Ragin, Camille C. R.
中科院分区：
文献类型：
--
作者：
Taioli, Emanuela;Sears, Vestra;Watson, Alexis;Flores-Obando, Rafael E.;Jackson, Maria D.;Ukoli, Flora A.;de Syllos Colus, Ilce M.;Fernandez, Pedro;McFarlane-Anderson, Norma;Ostrander, Elaine A.;Rodrigues, Iara S.;Stanford, Janet L.;Taylor, Jack A.;Tulloch-Reid, Marshall;Ragin, Camille C. R.
A meta and pooled analysis of published and unpublished case-control studies was peNorrformed to evaluate the association of CYP17 (rs743572) and CYP3A4 (rs2740574) polymorphisms and prostate cancer in men from the USA, Caribbean and Africa. Eight publications (7 studies) and two unpublished studies for CYP17 included 1,580 subjects (559 cases and 1,021 controls) and eleven publications and three unpublished studies for CYP3A4 included 3,400 subjects (1,429 cases and 1,971 controls). Overall, the CYP17 heterozygous and homozygous variants were not associated with prostate cancer, but they confer a 60% increased risk of prostate cancer in a sub-group analysis restricted to African-American men (T/C+C/C, OR: 1.6, 95% CI: 1.1–2.4). No associations were observed for CYP3A4, overall and in stratified analyses for African-Americans and Africans. The pooled analysis suggests that after adjusting for study, age, PSA and family history of prostate cancer, CYP17 was found to be associated with prostate cancer for men of African ancestry (Adjusted OR: 3.5, 95% CI: 1.2–10.0). Our findings suggest that genetic factors involved in the androgen pathway play a role in prostate cancer risk among men of African ancestry.
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影响因子：
3.7
作者：
Ragin CC;Taioli E;McFarlane-Anderson N;Avery G;Bennett F;Bovell-Benjamin A;Thompson AB;Carrington A;Campbell-Everett L;Ford J;Hennis A;Jackson M;Lake S;Leske MC;Magai C;Nemesure B;Neugut A;Odedina F;Okobia M;Patrick A;Plummer WB;Reams RR;Roberts R;Scott-Hastings S;Sharma S;Wheeler V;Wu SY;Bunker C
通讯作者：
Bunker C
影响因子：
3.9
作者：
Leitzmann MF;Rohrmann S
通讯作者：
Rohrmann S
影响因子：
3.1
作者：
dos Santos, Rodrigo Mattos;Nobrega de Jesus, Carlos Marcio;Rogatto, Silvia Regina
通讯作者：
Rogatto, Silvia Regina
影响因子：
2.1
作者：
Kaplan, Steven A.;Roehrborn, Claus G.;Vaughan, E. Darracott, Jr.
通讯作者：
Vaughan, E. Darracott, Jr.
影响因子：
3.5
作者：
CAREY, AH;WATERWORTH, D;WILLIAMSON, R
通讯作者：
WILLIAMSON, R