Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells.
Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells.
复制标题
美烯醇诱导的癌细胞凋亡的抗增生性和分子机制。
DOI：
10.3390/molecules17066290
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发表时间：
2012-05-25
期刊：
影响因子：
--
通讯作者：
Supriyanto E
中科院分区：
文献类型：
--
作者：
Jaganathan SK;Supriyanto E
酚类植物化学物质是在植物中发现的一类广泛的营养保健品，科学家们因其促进健康的潜力而进行了广泛的研究。丁香酚（4-烯丙基-2-甲氧基酚）是一种被广泛使用的化合物，它是丁香的活性成分。芳香植物如肉豆蔻、罗勒、肉桂和月桂叶也含有丁香酚。丁香酚有广泛的应用，如香水，香料，精油和在医药作为局部防腐剂和麻醉剂。越来越多的文献表明丁香酚具有抗氧化、抗诱变、抗基因毒性、抗炎和抗癌的特性。丁香酚诱导黑色素瘤、皮肤肿瘤、骨肉瘤、白血病、胃细胞和肥大细胞凋亡的分子机制已被广泛报道。本文就丁香酚诱导肿瘤细胞凋亡的抗增殖活性及分子机制及动物模型作一综述。
Phenolic phytochemicals are a broad class of nutraceuticals found in plants which have been extensively researched by scientists for their health-promoting potential. One such a compound which has been comprehensively used is eugenol (4-allyl-2-methoxyphenol), which is the active component of Syzigium aromaticum (cloves). Aromatic plants like nutmeg, basil, cinnamon and bay leaves also contain eugenol. Eugenol has a wide range of applications like perfumeries, flavorings, essential oils and in medicine as a local antiseptic and anesthetic. Increasing volumes of literature showed eugenol possesses antioxidant, antimutagenic, antigenotoxic, anti-inflammatory and anticancer properties. Molecular mechanism of eugenol-induced apoptosis in melanoma, skin tumors, osteosarcoma, leukemia, gastric and mast cells has been well documented. This review article will highlight the antiproliferative activity and molecular mechanism of the eugenol induced apoptosis against the cancer cells and animal models.
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DOI：
10.1016/j.jsbmb.2008.11.002
发表时间：
2009-01-01
影响因子：
4.1
作者：
Ghosh, Rita;Ganapathy, Manonmani;Kumar, Addanki P.
通讯作者：
Kumar, Addanki P.
影响因子：
4.8
作者：
Ghosh, R;Nadiminty, N;Kumar, AP
通讯作者：
Kumar, AP
影响因子：
4.6
作者：
Kaur, Gurpreet;Athar, Mohammad;Alam, M. Sarwar
通讯作者：
Alam, M. Sarwar
影响因子：
4.3
作者：
Kreydiyyeh, SI;Usta, J;Copti, R
通讯作者：
Copti, R
影响因子：
3.4
作者：
Manikandan, P.;Vinothini, G.;Nagini, S.
通讯作者：
Nagini, S.