Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders.
Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders.
复制标题
海马再生医学：成瘾和精神障碍的神经原性影响。
DOI：
10.1038/s12276-021-00587-x
复制
发表时间：
2021-03
影响因子：
12.8
通讯作者：
Jang MH
中科院分区：
文献类型：
--
作者：
Peyton L;Oliveros A;Choi DS;Jang MH
精神疾病是一种普遍存在且高度衰弱的疾病，在中等收入和高收入国家，超过50%的普通人群在一生中的某个时候至少经历过一种精神疾病。随着我们不断了解精神病发作在社会中的普遍程度，我们必须承认，精神病不仅仅局限于一小群有易感性的个体，而是发生在所有社会群体的重要部分。几个不同的大脑区域与神经精神疾病有关。这些大脑区域包括皮质边缘结构，其调节执行功能和决策（例如，前额叶皮层），以及已知在正常和压力条件下控制动机行为的纹状体亚区域。重要的是，皮质边缘神经回路包括海马体，海马体是一种重要的大脑结构，它向皮质和纹状体发送投射，以协调学习，记忆和情绪。在这篇综述中，我们将讨论过去和最近的发现如何在海马和皮质边缘结构的神经生物学过程中协同工作，以控制执行功能，记忆和情绪的背景下，精神障碍。大脑中有一个叫做海马体的区域，它通过所谓的皮质边缘结构与大脑的其他部分相连，这与各种心理健康障碍有关。这些疾病可伴有海马体积减少。美国罗切斯特马约临床医学与科学学院的Mi-Hyeon Jang、Doo-Sup Choi及其同事回顾了海马和皮质边缘神经生物学在精神障碍患者记忆和情绪中的作用。他们特别关注神经发生的作用，新神经细胞和连接的产生和生长。成年海马体中的神经发生中断与包括成瘾、抑郁症、精神分裂症和相关精神障碍在内的病症有关。更多地了解海马体中的神经再生可以深入了解心理健康状况，并为开发基于药物的治疗开辟新途径。
Psychiatric illness is a prevalent and highly debilitating disorder, and more than 50% of the general population in both middle- and high-income countries experience at least one psychiatric disorder at some point in their lives. As we continue to learn how pervasive psychiatric episodes are in society, we must acknowledge that psychiatric disorders are not solely relegated to a small group of predisposed individuals but rather occur in significant portions of all societal groups. Several distinct brain regions have been implicated in neuropsychiatric disease. These brain regions include corticolimbic structures, which regulate executive function and decision making (e.g., the prefrontal cortex), as well as striatal subregions known to control motivated behavior under normal and stressful conditions. Importantly, the corticolimbic neural circuitry includes the hippocampus, a critical brain structure that sends projections to both the cortex and striatum to coordinate learning, memory, and mood. In this review, we will discuss past and recent discoveries of how neurobiological processes in the hippocampus and corticolimbic structures work in concert to control executive function, memory, and mood in the context of mental disorders. A region of the brain called the hippocampus and its connections to other parts of the brain via what are called cortico-limbic structures are implicated in a variety of mental health disorders. These disorders can be accompanied by reduced hippocampal volume. Mi-Hyeon Jang, Doo-Sup Choi and colleagues at the Mayo Clinic College of Medicine and Science, Rochester, USA, review the role of hippocampal and cortico-limbic neurobiology in memory and mood in mental disorders. They focus particular attention on the role of neurogenesis, the production and growth of new nerve cells and connections. Disrupted neurogenesis in the adult hippocampus is implicated in conditions including addiction, depression, schizophrenia and related psychotic disorders. Learning more about neural regeneration in the hippocampus could yield insights into mental health conditions and open new avenues toward developing drug-based treatments.
登录
查看更多内容
影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
DOI：
10.1016/j.bbi.2017.05.006
发表时间：
2017-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Borsini A;Alboni S;Horowitz MA;Tojo LM;Cannazza G;Su KP;Pariante CM;Zunszain PA
通讯作者：
Zunszain PA
影响因子：
4.3
作者：
Bagasrawala I;Zecevic N;Radonjić NV
通讯作者：
Radonjić NV
影响因子：
3.7
作者：
Chandran JS;Kazanis I;Clapcote SJ;Ogawa F;Millar JK;Porteous DJ;Ffrench-Constant C
通讯作者：
Ffrench-Constant C
DOI：
10.1016/j.pnpbp.2014.05.003
发表时间：
2014-10-03
影响因子：
5.6
作者：
Geil, Chelsea R.;Hayes, Dayna M.;McClain, Justin A.;Liput, Daniel J.;Marshall, S. Alex;Chen, Kevin Y.;Nixon, Kimberly
通讯作者：
Nixon, Kimberly